SynthesisInternational journal of obesity (2005)2025
Are low carbohydrate diet interventions beneficial for metabolic syndrome and its components? A systematic review and meta-analysis of randomized controlled trials.
Synthesis in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of the ketogenic diet on the health of patients with metabolic syndrome: a scoping review.Frontiers in nutrition · 2026Pooled it
- Self-Reported Health Outcomes in Metabolic Health YouTube Comments: Cross-Sectional Study and Rule-Based Natural Language Processing Framework Development and Validation.Journal of medical Internet research · 2026Observational
- Evaluation of nutritional interventions and their impact on metabolic syndrome risk markers in older adults.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiet plays a crucial role in metabolic syndrome (MetS) which might develop into diabetes mellitus and cardiovascular disease.
objectiveWe aimed to evaluate the effects of low-carbohydrate diet (LCD) interventions on MetS and its components.
methodsFour electronic databases including PubMed, Embase, Cochrane Central Register of Controlled Trials, and Medline were selected from database inception until March 2024. Randomized clinical trials in adults with MetS evaluated LCD interventions (50-130 g of carbohydrates/day or 10-40% of total dietary energy at 2000 kcal/day) and a control intervention for at least 12 weeks. Four reviewers independently extracted data and assessed risk of bias using Cochrane tool. Meta-analyses used a random-effects model to calculate mean differences (MD) and 95% confidence intervals (CI) and analyzed heterogeneity, sensitivity, and publication bias.
resultsA total of 41 articles satisfied the study's inclusion criteria. Thirty articles were incorporated in the meta-analysis, of which 25 were high-quality studies and 5 were of moderate quality. In total, 3806 adults were assessed. Pooled analysis of mean differences (MD) indicated that compared to the control dietary intervention, the LCD intervention reduced BMI (MD -0.43 kg/m
conclusionIn summary, LCD interventions improved MetS-related biomarkers in adults with MetS. Moreover, further research is needed to determine the optimal intervention period of LCD on MetS.
Indexed as
Identifiers
40579564What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.