Evidence map›Paper›PMID 40579608›Full record

ArticleCellular and molecular life sciences : CMLS2025

Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.

Huimin Fu, Yang Yu, Shangyuan Wang, Peixian Xu, Yuting Sun, Jiaqi Li, Xiaoli Ge, Shuming Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Piezo1 mediates electrotaxis of alveolar epithelial cells via calcium-dependent PI3K/Akt signaling.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026
    Article
  5. The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.Apoptosis : an international journal on programmed cell death · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huimin FuDepartment of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yang YuDepartment of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Shangyuan WangDepartment of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Peixian XuDepartment of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yuting SunDepartment of Emergency, Putuo, Hospital Shanghai University of Traditional Chinese Medicine, No. 1665, Kongjiang Road, Yangpu District, Shanghai, 200433, China.
Jiaqi LiDepartment of Emergency, Putuo, Hospital Shanghai University of Traditional Chinese Medicine, No. 1665, Kongjiang Road, Yangpu District, Shanghai, 200433, China.
Xiaoli GeDepartment of Emergency, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, No. 639, Zhizaoju Road, Huangpu District, Shanghai, 200011, China. gexiaoli@sjtu.edu.cn.
Shuming PanDepartment of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China. panshuming1103@163.com.ORCID http://orcid.org/0000-0002-6922-5545

Funding

the Construction of Key Disciplines in the Health and Wellness System of Shanghai Municipality 2024tszk01the Key Discipline in the Health and Wellness System of Shanghai Municipality 2024ZDXK0005
6 · The paper itself

Abstract

Ischemic stroke (IS) leads to the disruption of blood-brain barrier (BBB) integrity, resulting in brain edema. In this process, endothelial cells, as a crucial component of the BBB, are subjected to external pressure and tensile stress. Piezo1, a mechanically-sensitive ion channel, may be activated by sensing these stresses, further exacerbating the destruction of the BBB. Our findings indicated that after cerebral ischemia/reperfusion (I/R) injury, the expression of Piezo1 in endothelial cells increased. In endothelial-specific Piezo1 knockout (Piezo1

Indexed as

Blood-Brain BarrierBrain IschemiaCalcium-Calmodulin-Dependent Protein Kinase Type 2Ion ChannelsIschemic StrokeNF-E2-Related Factor 2AnimalsEndothelial CellsMaleMiceMice, Inbred C57BLMice, KnockoutOxidative StressReperfusion InjuryCalcium-Calmodulin-Dependent Protein Kinase Type 2Ion ChannelsNfe2l2 protein, mouseNF-E2-Related Factor 2Piezo1 protein, mouseEndothelial dysfunctionMitochondrial dysfunctionNeuroinflammationOxidative stress

Identifiers

PMID40579608
PMCPMC12204977

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.