ReviewMedical gas research2026
Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting.
Review in Medical gas research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- From underwater physiology to intensive care: oxygen tolerance unit at the bedside.Critical care (London, England) · 2026Article
- Respiratory-physiology modeling of therapeutic hydrogen inhalation: defining the fraction of inspired hydrogen (FiHRespiratory research · 2026Article
- Precision Oxygen Therapy in the Intensive Care Unit: Matching Oxygen Exposure to Patient Phenotypes.Journal of personalized medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In clinical studies, the partial pressure of oxygen (PaO2) and oxygen pulse saturation are the main variables used to assess blood oxygenation and define the threshold of hypoxia/hyperoxia and hypoxemia/hyperoxemia. Determination of the optimal oxygenation target has generated a lot of interest in recent years, mainly because of the potential risk of worse outcomes associated with hyperoxia, whereas the risk associated with hypoxia has been already well known. In this short narrative review, we recall some fundamental elements of physiology regarding the meaning of PaO2, the diffusion of oxygen to cells, the definitions of hyperoxemia and hyperoxia and the mechanisms of oxygen toxicity to provide a better understanding of these concepts, to which intensive care clinicians are frequently confronted. PaO2 provides only limited information about oxygen concentration carried by blood and does not allow to determine whether cells are exposed to hyperoxia. This should be considered for the design of future studies that aim to determine optimal oxygenation target and by clinicians for their daily practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.