Evidence map›Paper›PMID 40580272›Full record

ReviewAging clinical and experimental research2025

Influenza vaccination in older people: a geriatrician's perspective.

Nicola Veronese, Ligia Juliana Dominguez, Antonina Ganci, Gerlando Speziale, Pasquale Mansueto, Salvatore Piro, Giorgio Basile, Mario Barbagallo

Abstract readReview
In one paragraph

Review in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicola VeroneseGeriatric Unit, Department of Medicine, University of Palermo, Palermo, Italy. nicola.veronese@unipa.it.
Ligia Juliana DominguezDepartment of Medicine and Surgery, University of Enna Kore, Enna, Italy.
Antonina GanciGeriatric Unit, Department of Medicine, University of Palermo, Palermo, Italy.
Gerlando SpezialeGeriatric Unit, Department of Medicine, University of Palermo, Palermo, Italy.
Pasquale MansuetoGeriatric Unit, Department of Medicine, University of Palermo, Palermo, Italy.
Salvatore PiroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Giorgio BasileUnit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico "G. Martino", 98124, Messina, Italy.
Mario BarbagalloGeriatric Unit, Department of Medicine, University of Palermo, Palermo, Italy.

Funding

Sanofi Italia not available
6 · The paper itself

Abstract

Influenza poses a significant threat to older adults, exacerbated by age-related immune decline and the high prevalence of chronic conditions. Despite being the most effective preventive measure, influenza vaccination rates among this population remain alarmingly low, with Italy and Europe failing to meet the World Health Organization’s target of 75% coverage for individuals aged 65 and over. This review, informed by a geriatric conference in Enna, Sicily, examines the epidemiology of influenza in older populations, the impact of frailty on vaccination, and specific considerations for patients with dementia and diabetes. High-dose (HD) and adjuvanted inactived vaccines emerge as vital tools, offering enhanced immunogenicity and efficacy tailored to the unique needs of older adults. Economic analyses underscore the high direct and indirect costs of influenza in older populations, advocating vaccination as a cost-effective intervention. The authors call for increased geriatrician advocacy, education of healthcare professionals, and tailored public health strategies to improve vaccine uptake, especially among frail individuals and those with dementia or diabetes. By addressing these gaps, influenza vaccination can significantly mitigate the clinical, economic, and social burdens of the disease in older adults. The review highlights barriers to vaccination, including healthcare workers’ hesitancy, misinformation, and logistical challenges in geriatric care settings. Enhanced vaccination strategies, particularly the use of HD vaccines, are shown to reduce hospitalizations, mortality, and healthcare costs. Furthermore, the integration of vaccination into life-course immunization policies is essential for minimizing disease burden and promoting healthy aging.

Indexed as

Influenza, HumanInfluenza VaccinesVaccinationAgedGeriatriciansHumansInfluenza VaccinesInfluenzaOlder peopleVaccination

Identifiers

PMID40580272
PMCPMC12206169

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.