Evidence map›Paper›PMID 40580958›Full record

ArticleCurrent biology : CB2025

Clock-dependent regulation of a homeostatic sleep center maintains daytime sleep and evening activity.

Cynthia T Hsu, Camilo Guevara, Samantha L Killiany, Joy Shon, Stephane Dissel, Amita Sehgal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026
    Article
  2. Article
  3. Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cynthia T HsuChronobiology and Sleep Institute and Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: cynthiahsu@mail.fresnostate.edu.
Camilo GuevaraChronobiology and Sleep Institute and Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Samantha L KillianyChronobiology and Sleep Institute and Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Joy ShonChronobiology and Sleep Institute and Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Stephane DisselDivision of Biological and Biomedical Systems, School of Science and Engineering, University of Missouri, Kansas City, Kansas City, MO 64110, USA.
Amita SehgalChronobiology and Sleep Institute and Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: amita@pennmedicine.upenn.edu.

Funding

Interaction between circadian and sleep circuitsR01NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AMITA SEHGAL · 2005 to 2026
$4.8M
NINDS NIH HHS R01 NS048471
6 · The paper itself

Abstract

Homeostatic sleep centers promote sleep in response to prolonged wakefulness, but their contribution to circadian-regulated daily sleep is still unclear. Do neuronal circuits driving rebound sleep after extended wakefulness also drive circadian-gated sleep, or does rebound sleep differ on a neurophysiological level from daily baseline sleep? We observed in Drosophila that 23E10+ neurons, which include a homeostatic sleep center, the dorsal fan-shaped body (dFSB),

Indexed as

Circadian ClocksCircadian RhythmDrosophila melanogasterSleepAnimalsDrosophila ProteinsHomeostasisNeuronsPeriod Circadian ProteinsDrosophila ProteinsPeriod Circadian Proteinscircadian clockDrosophilafan-shaped bodypigment dispersing factorsleep

Identifiers

PMID40580958
PMCPMC12316106

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.