ReviewVirology journal2025
Human papillomavirus infection in males: implications for fertility, assisted reproductive outcomes, and vaccination strategies.
Review in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Unfolding the Semen Microbiota: Implications for Male Infertility.Biomedicines · 2026Review
- Epigallocatechin gallate, folic acid, vitamin B12 and hyaluronic acid in the management of male Human Papilloma Virus Infection: A case series.SAGE open medical case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus (HPV), a prevalent sexually transmitted infection, is increasingly recognized as a critical determinant of male reproductive dysfunction. This comprehensive review consolidates evidence on HPV-mediated mechanisms impairing semen quality, inducing sperm DNA fragmentation, and facilitating paternal-fetal transmission, which collectively contributes to spontaneous abortion and assisted reproductive technology (ART) failure. While debates persist on the direct causal role of HPV in infertility, emerging data highlight the efficacy of male vaccination in reducing the seminal viral load, improving pregnancy rates, and lowering miscarriage risk. We propose integrating HPV screening into male fertility assessments and advocating gender-neutral vaccination programs to increase ART success and mitigate vertical transmission. Future research should delineate HPV-induced epigenetic alterations and validate novel sperm preparation techniques for optimizing reproductive outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.