Evidence map›Paper›PMID 40581749›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2025

N-palmitoyl glycine mediates depression-associated atrial fibrillation via Man1a2-dependent autophagy and NRAP dysregulation.

Jiuling Chen, Siqi Sheng, Jinhui Zhang, Yuchen Li, Tingting Jiang, Xiaohui Jiang, Jiahao Li, Lin Lv, Zhiqi Wang, Yongkang Wei and 7 more

Abstract read
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In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiuling ChenDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.ORCID 0009-0001-7236-3615
Siqi ShengThe Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.ORCID 0009-0008-8125-9722
Jinhui ZhangDepartment of Psychiatry, The First Special Hospital of Harbin, 10 Weixing Road, Harbin, Heilongjiang Province 150026, China.
Yuchen LiDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.ORCID 0000-0001-9879-1207
Tingting JiangDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Xiaohui JiangDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Jiahao LiThe Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Lin LvThe Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Zhiqi WangDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.ORCID 0009-0007-8430-2178
Yongkang WeiDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Ning FangDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Song ZhangDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Hong YaoDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Yanghong DongDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.ORCID 0009-0008-2682-3917
Zheng XueDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Zengxiang DongThe Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.
Zhaoguang LiangDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin, Heilongjiang Province 150001, China.ORCID 0009-0002-0215-8218

Funding

Ministry of Science and Technology of the People's Republic of China 2017YFC1307700Ministry of Science and Technology of the People's Republic of China 2017YFC1307704Ministry of Science and Technology of the People's Republic of China 2018YFC1311604Scientific Research Project of the Health and Family Planning Commission of Heilongjiang Province 2017-036
6 · The paper itself

Abstract

aimsAlthough many large-scale clinical studies have confirmed that depression is an independent risk factor for atrial fibrillation (AF), the underlying mechanism remains unclear. This study aimed to investigate the pathogenesis of depression-associated AF. METHODS AND

resultsThe chronic unpredictable mild stress model of depression was established. In this model, we observed a significant increase in AF inducibility. In order to explore its potential mechanism, we analysed the serum metabolomics of humans and rats and the protein metabolomics of atrial tissue in rats. The levels of N-palmitoyl glycine in different tissues were quantified using liquid chromatography-mass spectrometry. Both in vivo and in vitro experiments were performed to validate the proposed mechanisms. Electrophysiological changes in isolated hearts were evaluated using the Langendorff perfusion system and multi-channel electrical mapping. Our findings suggest that N-palmitoyl glycine secreted by the white matter acts as a key factor in depression-associated AF. Both in vivo and in vitro experiments revealed that N-palmitoyl glycine reduces autophagy and the synthesis of nebulin-related anchoring protein in atrial myocytes by up-regulating α1,2-mannosidase expression. These changes lead to the intercalated disc rupture, a critical event in the pathogenesis of AF.

conclusionThis study demonstrates that N-palmitoyl glycine plays a crucial role in the development of AF in the context of depression. These findings provide potential therapeutic targets for the prevention and treatment of AF following depression.

Indexed as

Atrial FibrillationAutophagyDepressionGlycineMyocytes, CardiacAction PotentialsAnimalsDisease Models, AnimalHeart AtriaHeart RateHumansMaleRatsRats, Sprague-DawleyGlycineAtrial fibrillationAutophagyDepressionNebulin-related anchoring proteinN-palmitoyl glycineα1, 2-mannosidase

Identifiers

PMID40581749
PMCPMC12246679

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.