ArticleGut microbes2025
Intestinal host-microbe interactions fuel pulmonary inflammation in cigarette smoke exposed mice.
Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Gut Microbiota in Addiction Biology: A Systematic Review of Substance-Induced Dysbiosis and Gut-Brain Axis Alterations.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Tumor-Associated Neutrophils in Advanced Non-Small Cell Lung Cancer Patients Predicted by Clinicopathologic Characteristics and Peripheral Blood Markers.Saudi medical journal · 2026Article
- Microbial activation of the GLP-2R mitigates gastrointestinal inflammation.Nature communications · 2026Article
- Exercise prescription for mood and cognition: targeting the microbiota-gut-brain axis through short-chain fatty acids.Frontiers in microbiology · 2026Review
- Gut microbiota dysbiosis and the gut-lung axis in COPD: mechanisms, clinical relevance, and microbiota-targeted interventions.Frontiers in cell and developmental biology · 2026Review
- Characterisation of the gut-lung axis microbiome in clinically stable patients with chronic obstructive pulmonary disease.EBioMedicine · 2026Observational
- Multifaceted effects of the microbiome in pancreatic cancer: from association to modulation.Nature reviews. Gastroenterology & hepatology · 2025Review
- Airway microbiota and immunity associated with chronic obstructive pulmonary disease severity.Journal of translational medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota has been implicated in numerous aspects of host health and immune regulation. Specifically, recent studies have linked gut microbes to the pathogenesis of chronic obstructive pulmonary disease (COPD), primarily induced by excessive cigarette smoke, although the underlying mechanisms remain elusive. Here, we investigated the role of gastrointestinal (GI) host-microbe interactions on pulmonary health. Using two distinct means of modulating GI host-microbe relations, we dissected how gut microbes fuel pulmonary inflammation in mouse models of cigarette smoke (CS)-induced lung disease. We found that CS caused profound changes to the colonic mucosa, with reduced mucus and increased bacterial encroachment. Modulating host-microbe interactions using antibiotics and recombinant human β-defensin 2 restricted colonic bacterial encroachment, limiting interactions between host and microbe. These strategies resulted in substantial ~50% decrease in pulmonary neutrophil infiltration following both acute and chronic exposure to CS. The reported findings provide additional evidence of a gut-lung axis, offering novel insight into the role of the gut microbiota in pulmonary immune activation, which could represent a novel avenue for future therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.