ReviewChemistry & biodiversity2025
Theoretical Analysis of d-Serine and d-Asparagine as Biomarkers for Glomerular Filtration Rate.
Review in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Alterations of Plasma Metabolites Associated with Sickle Cell Trait.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Theoretical Analysis of d-Serine and d-Asparagine as Biomarkers for Glomerular Filtration Rate.Chemistry & biodiversity · 2025Review
- d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection.Chembiochem : a European journal of chemical biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Chronic kidney disease (CKD) is a major global health issue, requiring accurate and noninvasive renal function assessment. Glomerular filtration rate (GFR) is the standard measure, but current methods, including inulin clearance and creatinine-based estimation, have limitations in accuracy, invasiveness, and practicality. We investigated d-serine and d-asparagine as novel endogenous biomarkers for GFR evaluation. Their clearance strongly correlates with inulin clearance, demonstrating high reliability and reduced muscle mass dependency compared to creatinine-based methods. Our findings suggest that d-amino acids offer a promising, less invasive alternative for precise renal function assessment, aiding early CKD detection and management. In addition, d-amino acids have recently been reported to be useful as biomarkers not only in the renal field but also in various other fields such as malignancy and infectious diseases. This article highlights the potential of d-amino acids in enhancing CKD diagnosis and management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.