Evidence map›Paper›PMID 40583123›Full record

ArticleAging cell2025

Impaired Cytokine Secretion Contributes to Age-Dependent Immune Dysfunction in SARS Coronavirus Response and Is Restored by Young CD11b-Positive Cell Transfer.

Yu-Xuan Wu, Chih-Wei Hu, Jui-Yu Chang, Shuoh-Wen Chen, Ting-An Lin, Eric Chang-Yi Lin, Min-Hui Chen, Chuen-Mi Yang, Hsuan-Ying Lu, Ching-Jung Teng and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yu-Xuan WuInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.ORCID 0000-0002-4343-0102
Chih-Wei HuExperimental Animal Center, Institute of Preventive Medicine, National Defense Medical College, New Taipei City, Taiwan.ORCID 0000-0001-9836-8644
Jui-Yu ChangDepartment of Biotechnology and Laboratory Science in Medicine, College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei City, Taiwan.ORCID 0009-0001-4337-2766
Shuoh-Wen ChenInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.ORCID 0000-0001-9344-082X
Ting-An LinInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Eric Chang-Yi LinInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.ORCID 0000-0003-0118-0448
Min-Hui ChenInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.ORCID 0009-0000-5779-0347
Chuen-Mi YangExperimental Animal Center, Institute of Preventive Medicine, National Defense Medical College, New Taipei City, Taiwan.ORCID 0009-0006-5646-6135
Hsuan-Ying LuExperimental Animal Center, Institute of Preventive Medicine, National Defense Medical College, New Taipei City, Taiwan.ORCID 0000-0002-8676-3484
Ching-Jung TengSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.ORCID 0009-0001-4607-6102
Yuan-I ChangInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.ORCID 0000-0002-2035-2818

Funding

National Science and Technology Council MOST 108-2320-B-010-043-MY3National Science and Technology Council MOST 111-2320-B-A49-010-MY3Yen Tjing Ling Medical Foundation CI-113-20
6 · The paper itself

Abstract

COVID-19 mortality disproportionately affects the elderly, yet the cellular and molecular factors contributing to age-related immune system remodeling remain unclear. Using SARS-CoV-derived ssRNA sequences, we modeled age-dependent immune responses in mice. Aged mice exhibited higher mortality and severe lung inflammation upon viral ssRNA challenge, mirroring clinical observations. We uncovered a pre-existing inflammatory state in aged mice, characterized by elevated baseline levels of specific immune cells and cytokines correlating with poor outcomes. Age-related immune dysfunction stemmed from impaired IRF7 signaling and defective SNARE-mediated cytokine secretion in CD11b

Indexed as

Adoptive TransferAgingCD11b AntigenCOVID-19CytokinesSARS-CoV-2Age FactorsAnimalsHumansInterferon Regulatory Factor-7MaleMiceMice, Inbred C57BLCD11b AntigenCytokinesInterferon Regulatory Factor-7aginginnate immunityIRF7SARS‐CoVSNARE

Identifiers

PMID40583123
PMCPMC12419839

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.