Evidence map›Paper›PMID 40583282›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Calcitonin Gene-Related Peptide (CGRP)-Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain-Induced Sleep Disturbances.

Nicole Lynch, Roberto De Luca, Richard L Spinieli, Enrico Rillosi, Renner C Thomas, Samuel Sailesh, Nishta Gangeddula, Janayna D Lima, Sathyajit S Bandaru, Elda Arrigoni and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicole LynchDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Roberto De LucaDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID 0000-0001-8105-426X
Richard L SpinieliDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID 0000-0001-9601-3444
Enrico RillosiDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Renner C ThomasDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Samuel SaileshDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Nishta GangeddulaDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Janayna D LimaDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID 0000-0002-7229-8446
Sathyajit S BandaruDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Elda ArrigoniDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID 0000-0002-4391-6700
Agustin Melo-CarrilloDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Rami BursteinDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID 0000-0003-3763-8916
Stephen ThankachanBoston VA Research Institute, Veterans Affairs Boston Healthcare System & Department of Psychiatry, Harvard Medical School, West Roxbury, MA, 02132, USA.ORCID 0000-0002-7499-9019
Satvinder KaurDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID 0000-0002-8243-2880

Funding

Project 5: Novel strategies to prevent opioid-induced hypoventilation during sleep and identification of underlying mechanismsP01HL149630 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD B SAPER · 2020 to 2026
$22.3M
Dissection of the Circuitry Regulating Arousal to PainR01NS112175 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAUR, SATVINDER · 2019 to 2023
$1.9M
NHLBI NIH HHS HL149630-01NHLBI NIH HHS P01 HL149630NINDS NIH HHS NS112175NINDS NIH HHS R01 NS112175
6 · The paper itself

Abstract

Given that sleep and pain are bidirectionally related, we investigated the neural circuits underlying pain-induced sleep disturbances using two acute pain models. Activation of nociceptors in acute inflammatory pain (AIP) significantly reduced sleep by 45-50% in the first 6 h, with reduced sleep spindle density for 1-3 h post-AIP. Additionally, an "optogenetic pain (Opto-Pain)" model is implemented to produce acute peripheral pain-induced awakenings that reduced sleep comparable to AIP. Both pain models are used to test the role of wake-promoting neurons in the parabrachial nucleus that express Calcitonin Gene-Related Peptide (PBel

Indexed as

Calcitonin Gene-Related PeptideNeuronsPainParabrachial NucleusSleep Wake DisordersAnimalsDisease Models, AnimalMaleMiceNociceptorsCalcitonin Gene-Related Peptideacute painneural‐circuitsoptogeneticsparabrachial nucleussleep‐loss

Identifiers

PMID40583282
PMCPMC12463127

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.