Evidence map›Paper›PMID 40583297›Full record

ArticleJournal of cellular biochemistry2025

Sweet Science: Exploring the Impact of Fructose and Glucose on Brown Adipocyte Differentiation Using Optical Diffraction Tomography.

Pooja Anantha, Xiangdong Wu, Salaheldeen Elsaid, Piyush Raj, Junkai Hu, Ishan Barman, Sui Seng Tee

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Pooja AnanthaDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Xiangdong WuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Salaheldeen ElsaidDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-8362-9378
Piyush RajDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Junkai HuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Ishan BarmanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Sui Seng TeeDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-9891-4622

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Longitudinal Metabolic Imaging of the Brain in SynucleinopathyR21AG084142 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SON, JUNSEOK, TEE, SUI SENG · 2023 to 2025
$1.3M
Fructose Metabolism as a Biomarker for Monitoring Hepatocellular CarcinomaR21CA245492 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI TEE, SUI SENG · 2020 to 2020
$397k
NCATS NIH HHS UL1 TR003098NCI NIH HHS P30 CA134274NCI NIH HHS R21 CA245492NIA NIH HHS R21 AG084142This study was supported in part by US National Institute of Health (NIH) grants R21CA245492 and R21AG084142. The authors acknowledge the support of the University of Maryland, Baltimore, Institute for Clinical & Translational Research (ICTR) and the National Center for Advancing Translational Sciences (NCATS) Clinical Translational Science Award (CTSA) Grant Number 1UL1TR003098. The authors also acknowledge the support of the National Cancer Institute-Cancer Center Support Grant (CCSG)-P30CA134274, as well as the Maryland Department of Health's Cigarette Restitution Fund Program CH-649-CRF.
6 · The paper itself

Abstract

The thermogenic capacity of brown adipose tissue (BAT) has garnered much attention for its potential to regulate systemic energy balance. BAT depot size and function need to be tightly regulated to prevent loss of metabolic homeostasis due to energy dissipation via non-shivering thermogenesis. While adipocyte-intrinsic mechanisms controlling thermogenesis are critical, an increasing appreciation for the role of the BAT microenvironment is emerging. For example, changes in circulating hexoses due to dietary intake have shown to impact BAT function. Here, we show that murine BAT preadipocytes metabolism is impacted when fructose is used as the sole carbon source. Similarly, differentiation medium containing only fructose yield mature adipocytes with fewer lipid droplets, with a concomitant decrease in adipogenic genes. These deficiencies are also observed in human BAT preadipocytes, where cutting-edge optical imaging modalities show a decrease in total cell mass and lipid mass in fructose-only medium. Taken together, the metabolic microenvironment significantly impacts BAT growth and function, with implications for the role of diets potentially mitigating the efficacy of BAT-targeted therapies.

Indexed as

Adipocytes, BrownCell DifferentiationFructoseGlucoseAdipogenesisAdipose Tissue, BrownAnimalsHumansMiceThermogenesisFructoseGlucosefructoseglucosehuman brown adipose tissuehuman brown preadipocytelipidmetabolismoptical diffraction tomography

Identifiers

PMID40583297
PMCPMC12207058

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.