ArticleVeterinary world2025
Histological response and blood glucose level in a diabetic animal model after the oral administration of
Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background and Aim: Material and Methods: A systematic literature search was conducted across four databases (PubMed, Scopus, ScienceDirect, and Google Scholar) without date restrictions. Eligible Results: Sixteen studies were included, with 13 eligible for meta-analysis. MP extract significantly reduced blood glucose levels, with an overall standardized mean difference of -18.36 (95% confidence intervals: -21.22, -15.51; p < 0.01). Subgroup analyses revealed that lower MP doses (≤100 mg/kg) achieved superior glycemic control with prolonged administration (>4 weeks), whereas higher doses (≥200 mg/kg) were most effective within 1-4 weeks. Histological analysis indicated regenerative effects of MP on the pancreas, liver, pituitary gland, and corpus cavernosum. Seed extracts exhibited a stronger hypoglycemic effect compared to leaf extracts. Potential publication bias was detected but was addressed through trim-and-fill analysis. Conclusion: MP extract demonstrates significant antidiabetic potential through glycemic regulation and organ tissue restoration. Lower concentrations are preferable for long-term administration, while higher concentrations are optimal for short-term therapy. The findings advocate MP as a valuable candidate for integrative diabetes management strategies. Further clinical studies are recommended to validate its translational potential.
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