Evidence map›Paper›PMID 40584147›Full record

ArticleGastroenterology report2025

BMP6 ubiquitination mediated by SMURF1 suppresses ferroptosis and diminishes sensitivity to doxorubicin in gastric cancer.

Shuzhen Xu, Qingqi Zheng, Chunlin Chen, Zhenfa Wang, Guoyan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology report, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuzhen XuDepartment of Gastrointestinal Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, P. R. China.
Qingqi ZhengDepartment of Anesthesiology, Zhongshan Hospital Xiamen University, Xiamen, Fujian, P. R. China.
Chunlin ChenDepartment of Geriatrics, Zhongshan Hospital Xiamen University, Xiamen, Fujian, P. R. China.
Zhenfa WangDepartment of Gastrointestinal Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, P. R. China.
Guoyan LiuDepartment of Gastrointestinal Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of bone morphogenetic protein 6 (BMP6) is found to be associated with gastric cancer development. Here, we further explored the functions of BMP6 in gastric cancer cell malignant behaviors, ferroptosis, and doxorubicin sensitivity and the mechanism driving BMP6 dysregulation. BMP6 mRNA detection was performed by quantitative polymerase chain reaction, and protein expression was tested by immunoblotting and immunohistochemistry. Subcutaneous xenograft studies were used to analyze

Indexed as

BMP6doxorubicin resistanceferroptosisgastric cancerubiquitination

Identifiers

PMID40584147
PMCPMC12202749

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.