Evidence map›Paper›PMID 40584439›Full record

ReviewIranian journal of basic medical sciences2025

Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies.

Mohamed Javad Saadh, Sarraa Ahmad Qahtan, Rafid Jihad Albadr, Gaurav Sanghvi, Rangaswamy Roopashree, Aditya Kashyap, A Sabarivani, Jasur Rizaev, Waam Mohammed Taher, Mariem Alwan and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohamed Javad SaadhFaculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Sarraa Ahmad QahtanDepartment of Anesthesia Techniques, Health and Medical Techniques College, Alnoor University, Mosul, Iraq.
Rafid Jihad AlbadrAhl al Bayt University, Karbala, Iraq.
Gaurav SanghviMarwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot-360003, Gujarat, India.
Rangaswamy RoopashreeDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Aditya KashyapCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
A SabarivaniDepartment of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
Jasur RizaevDepartment of Public Health and Healthcare Management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, Uzbekistan.
Waam Mohammed TaherCollege of Nursing, National University of Science and Technology, Dhi Qar, Iraq.
Mariem AlwanPharmacy college, Al-Farahidi University, Iraq.
Mahmod Jasem JawadDepartment of Pharmacy, Al-Zahrawi University College, Karbala, Iraq.
Ali M Ali Al-NuaimiGilgamesh Ahliya University, Baghdad, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA types, have emerged as key regulators in neurodegenerative diseases and brain tumors. This review aims to provide insights into the role of ncRNAs in these conditions and their potential as diagnostic and therapeutic targets. We systematically reviewed literature from databases such as PubMed, Scopus, and Web of Science, applying specific inclusion and exclusion criteria to ensure comprehensive coverage of recent advancements. Although ncRNAs are involved in a range of molecular pathways, challenges in clinical translation, including specificity, cost, and validation, persist. This review highlights innovative strategies to overcome these barriers and promote the clinical application of ncRNAs. Moreover, we explore the emerging role of extracellular vesicle-enriched ncRNAs as cell-free therapeutic options for neurodegenerative diseases. The findings presented here emphasize the need for robust validation and the development of specific ncRNA-based treatments.

Indexed as

Alzheimer’s diseaseBrain cancerExtracellular vesicles GliomaLong non-coding RNAMicroRNA Neurodegenerative diseasesNon-coding RNA

Identifiers

PMID40584439
PMCPMC12203828

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.