Evidence map›Paper›PMID 40584580›Full record

ArticleEuropean heart journal open2025

Sex differences based on the timing of invasive management among patients with non-ST-elevation acute coronary syndrome: an individual patient data meta-analysis.

Graziella Pompei, Gregory B Mills, Christos P Kotanidis, Shamir Mehta, Denise Tiong, Erik A Badings, Thomas Engstrøm, Arnoud W J Van't Hof, Dan Høfsten, Lene Holmvang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Graziella PompeiTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0003-1901-0703
Gregory B MillsTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0002-7981-3594
Christos P KotanidisTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Shamir MehtaPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, 237 Barton Street, East Hamilton, ON, L8L 2X2, Canada.
Denise TiongPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, 237 Barton Street, East Hamilton, ON, L8L 2X2, Canada.
Erik A BadingsDepartment of Cardiology Research, Deventer Hospital, Nico Bolkesteinlaan 75, 7416 SE Deventer, The Netherlands.
Thomas EngstrømDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-5436-9194
Arnoud W J Van't HofDepartment of Cardiology, Maastricht University Medical Center, P. Debyelaan 25, 6229 ET Maastricht, The Netherlands.
Dan HøfstenDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Lene HolmvangDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-0941-378X
Alexander JobsHeart Center Leipzig at Leipzig University and Leipzig Heart Science, Strümpellstr. 39, 04289 Leipzig, Germany.
Lars KøberDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-6635-1466
Dejan MilasinovicFaculty of Medicine, University of Belgrade, dr Subotića starijeg 8, 11000 Belgrade, Serbia.ORCID https://orcid.org/0000-0002-1528-5147
Aleksandra MilosevicFaculty of Medicine, University of Belgrade, dr Subotića starijeg 8, 11000 Belgrade, Serbia.
Goran StankovicFaculty of Medicine, University of Belgrade, dr Subotića starijeg 8, 11000 Belgrade, Serbia.
Holger ThieleHeart Center Leipzig at Leipzig University and Leipzig Heart Science, Strümpellstr. 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0003-4495-4597
Roxana MehranMount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029-6574, USA.
Vijay KunadianTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID https://orcid.org/0000-0003-2975-6971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Studies investigating the timing of coronary angiography in non-ST-elevation acute coronary syndrome (NSTE-ACS) have not evaluated sex differences. This study aims to investigate the sex-related differences in outcomes of NSTE-ACS patients undergoing early or delayed invasive management. Methods and results: An individual patient data (IPD) meta-analysis was performed after systematic review of randomized controlled trials (RCTs) comparing early vs. delayed invasive strategy among NSTE-ACS patients. The primary endpoint was a composite of all-cause death or myocardial infarction (MI) at 6 months. Secondary endpoints included all-cause death, MI, recurrent ischaemia, stroke, and major bleeding. One-stage, random-effects Cox models were conducted. This meta-analysis was registered with PROSPERO (CRD42023468604). Six RCTs including 6654 patients were identified, of whom 2257 (33.9%) were females with a median age of 69 years [interquartile range (IQR) 60-76], significantly higher than males (64.5 years, IQR 55-72.1, Conclusion: No sex-related differences in the composite of all-cause death or MI were identified among NSTE-ACS patients undergoing early and delayed invasive management.

Indexed as

Delayed invasive strategyEarly invasive strategyFemaleNon-ST-elevation acute coronary syndromePercutaneous coronary interventionSex

Identifiers

PMID40584580
PMCPMC12202155

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.