ArticleEuropean heart journal open2025
Oxygen supplementation in ambulatory patients with heart failure: a randomized proof-of-concept study.
Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07613762 (Effect of High-Flow Nasal Cannula Use on Exercise Tolerance and Physical Performance in Heart Failure Patients Enrolled in a Cardiac Rehabilitation Program), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of High-Flow Nasal Cannula Use on Exercise Tolerance and Physical Performance in Heart Failure Patients Enrolled in a Cardiac Rehabilitation Program: A Randomized Crossover Trial
Who cites it
2 citing papers in PubMed.
- Hyperoxia in the exercising failing heart: beneficial or detrimental?European heart journal open · 2025Article
- Authors' response: Oxygen therapy in heart failure.European heart journal open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: The aims of this study were to describe the short-term effects of oxygen therapy on the physiological response and symptoms during ambulation in patients with chronic heart failure (HF). Methods and results: In this pilot, cross-over, randomized study, subjects with chronic HF underwent two 6-min walk tests (6MWTs) on the same day. They were randomized to either receive oxygen through a portable oxygen concentrator (POC ON) during the first test and no oxygen (POC OFF) during the second test, or vice versa. Endpoints included (i) peripheral oxygen saturation, (ii) heart rate, and (iii) modified BORG scale. A linear mixed model for repeated measures was used for comparisons. A total of 20 participants were included, aged 70 ± 10 years, with the mean left ventricular ejection fraction 33% ± 10% and N-terminal pro-B-type natriuretic peptide 1115 ± 1625 pg/mL. There was no difference in distance walked with or without oxygen supplementation. Oxygen saturation during 6MWT was higher with POC ON [3 min, SpO Conclusion: Our results suggest that for a same amount of physical activity, supplemental oxygen can improve peripheral oxygen saturation and breathlessness in symptomatic patients with chronic HF.
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Registered trials
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