Evidence map›Paper›PMID 40585139›Full record

ArticlemedRxiv : the preprint server for health sciences2025

A High-Performance Liquid Chromatography-Mass Spectrometry method for simultaneous determination of dolutegravir, nevirapine, efavirenz, rifampicin and rifapentine concentrations in human plasma.

Denis Omali, Moses Ocan, Hindum Lanyero, Martin Kamilo Angwe, Barbara Castelnuovo, Allan Buzibye

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Denis OmaliDepartment of Pharmacology and Therapeutics, College of Health Sciences, Makerere University, Kampala, Uganda.
Moses OcanDepartment of Pharmacology and Therapeutics, College of Health Sciences, Makerere University, Kampala, Uganda.
Hindum LanyeroDepartment of Pharmacology and Therapeutics, College of Health Sciences, Makerere University, Kampala, Uganda.
Martin Kamilo AngweDepartment of Pharmacology and Therapeutics, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID 0000-0002-1211-7762
Barbara CastelnuovoInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Allan BuzibyeInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Funding

HIV Co-infections in Uganda: TB, Cryptococcus, and Viral Hepatitis.D43TW009771 · FIC · JOHNS HOPKINS UNIVERSITY · PI CASTELNUOVO, BARBARA, KAMBUGU, ANDREW DDUNGU · 2014 to 2023
$3.3M
FIC NIH HHS D43 TW009771
6 · The paper itself

Abstract

Variations in clinical pharmacokinetics and genetics, and polypharmacy affect attainment of target drug concentrations in HIV-TB co-infected patients. However, scarcity of analytical methods hinders drug concentration measurement for therapeutic drug monitoring in this doubly vulnerable population in low-and-middle income countries. This study aimed to develop and validate an LC-MS method for simultaneous determination of dolutegravir, nevirapine, efavirenz, rifampicin, isoniazid and rifapentine concentrations in plasma. ThermoScientific LCQ ion trap operated by Xcalibur

Indexed as

analytical method development and validationHIV-TB patientsLC-MSPlasmatherapeutic drug monitoring

Identifiers

PMID40585139
PMCPMC12204419

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.