Evidence map›Paper›PMID 40585229›Full record

ArticleResearch square2025

Treatment with mitochondrial targeting antibiotics improves survival outcomes after Flock House virus infection in young and aged Drosophila melanogaster.

Dean Bunnell, Madelyn Buhl, Justin McGee, Grace Milas, Stanislava Chtarbanova

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dean BunnellUniversity of Alabama.
Madelyn BuhlUniversity of Alabama.
Justin McGeeUniversity of Alabama.
Grace MilasUniversity of Alabama.
Stanislava ChtarbanovaUniversity of Alabama.

Funding

Mechanisms underlying aged host-virus interactionsR01AG079962 · NIA · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI Stanislava Chtarbanova · 2024 to 2026
$2.8M
Temporal responses in host-virus interactionsR15AI169146 · NIAID · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI CHTARBANOVA, STANISLAVA · 2023 to 2023
$447k
NIAID NIH HHS R15 AI169146NIA NIH HHS R01 AG079962
6 · The paper itself

Abstract

Aged organisms are more susceptible to infectious diseases, including infections with RNA viruses. Mitochondrial dysfunction is one of many hallmarks of aging that could affect this increased susceptibility, as the relationship between immunity and metabolism is crucial to manage infections. Using

Indexed as

agingantibioticsDrosophila melanogasterinnate immunitymitochondrial unfolded protein responsevirus infection

Identifiers

PMID40585229
PMCPMC12204497

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.