Evidence map›Paper›PMID 40585362›Full record

ArticleiScience2025

Benzyl isothiocyanate induces heart regeneration.

Akane Sakaguchi, Miwa Kawasaki, Yuichi Saito, Kozue Murata, Hidetoshi Masumoto, Wataru Kimura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akane SakaguchiRIKEN Center for Biosystems Dynamics Research, Minatojima-Minamimachi 2-2-3, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Miwa KawasakiRIKEN Center for Biosystems Dynamics Research, Minatojima-Minamimachi 2-2-3, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Yuichi SaitoRIKEN Center for Biosystems Dynamics Research, Minatojima-Minamimachi 2-2-3, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Kozue MurataRIKEN Center for Biosystems Dynamics Research, Minatojima-Minamimachi 2-2-3, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Hidetoshi MasumotoRIKEN Center for Biosystems Dynamics Research, Minatojima-Minamimachi 2-2-3, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Wataru KimuraRIKEN Center for Biosystems Dynamics Research, Minatojima-Minamimachi 2-2-3, Chuo-ku, Kobe 650-0047, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian cardiomyocytes are arrested from the cell cycle shortly after birth, and therefore mammals lose the ability to regenerate injured myocardium for the rest of their lives. Pharmacological induction of cardiomyocyte proliferation has gained a lot of interest in recent years, as researchers strive to achieve heart tissue regeneration. Here, we show that a small chemical, benzyl isothiocyanate (BITC), induced cardiomyocyte proliferation through activation of the mitogen-activated protein kinase (MAPK) pathway. BITC treatment also allowed heart regeneration in the infarcted neonatal heart, even after the regeneration period in mice. Furthermore, administration of BITC to adult mice in parallel with mild hypoxia (10% O

Indexed as

Biological sciencesCardiovascular medicineCell biologyMolecular biology

Identifiers

PMID40585362
PMCPMC12205616

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.