ArticleFrontiers in psychiatry2025
Efficacy of non-wearable VR-based behavioral training for preschool children with high-functioning autism spectrum disorder: a protocol for an upcoming randomized clinical trial.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Response Inhibition in Autistic Adults: A Functional Near-Infrared Spectroscopy Study in Virtual Reality.Brain and behavior · 2026Article
- Novel therapeutics in autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Autism spectrum disorder (ASD) is a neurodevelopmental condition with limited effective treatment options, including Applied Behavior Analysis, Transcranial Magnetic Stimulation, and certain medications aimed at managing associated behavioral and emotional regulation challenges. Primary interventions include educational training and behavioral modifications. However, long-term, intensive, and individualized rehabilitation training strategies are lacking, and new rehabilitation tools therefore urgently need to be developed. Virtual reality (VR) is a promising digital rehabilitation tool that may support the development of essential life skills, such as social communication and daily living abilities, in many children and adolescents with ASD. Herein, we introduce a protocol for an initial multicenter randomized controlled trial focused on preschool-aged children with ASD. This trial aims to investigate the clinical efficacy of behavioral training for young children with ASD utilizing VR technology. Methods: A total of 160 children aged 4-7 years with high-functioning ASD will be assigned to either the trial or control group in a 1:1 ratio. The trial group will undergo behavioral training based on VR technology and early family intervention guided by the rehabilitation team, whereas the control group will undergo early family intervention guided by the rehabilitation team. Both arms will undergo twice weekly sessions of either the trial or control intervention modality performed over 12 consecutive weeks. Outcome assessments will be performed at the start of the trial, throughout the intervention phase, and at follow-up intervals during the study. Discussion: The primary aim of this trial is to determine the clinical effectiveness of cognitive training using VR technology in children with ASD. Clinical trial registration: Chinese Clinical Trial Registry identifier, ChiCTR2400094189.
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