ArticleJournal of the Endocrine Society2025
A Comparison of SGLT2 or DPP-4 Inhibitor Monotherapy vs Placebo for Type 2 Diabetes in Adolescents vs Young Adults.
Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Impact of Empagliflozin on Glomerular Hyperfiltration and Albuminuria in Youth with Type 2 Diabetes: Post Hoc Analysis of DINAMO.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Context: There is an unmet need for type 2 diabetes (T2D) treatments in addition to metformin and insulin for adolescents. This is due to the challenges of monotherapy in youth with T2D and need for treatment escalation to maintain glycemic control in youth generally more so than in young adults. Objective: We assessed the efficacy and safety of sodium-glucose co-transporter-2 (SGLT2) or dipeptidyl peptidase-4 (DPP-4) inhibitor monotherapies in adolescents and young adults with T2D not on active therapy. Methods: Drug-naïve adolescents and those not on active therapy received the SGLT2 inhibitor empagliflozin, the DPP-4 inhibitor linagliptin, or placebo for 26 weeks; young adults with no antidiabetic background therapy received empagliflozin, the DPP-4 inhibitor sitagliptin, or placebo for 24 weeks. The primary endpoint was treatment failure occurrence. Secondary outcomes assessed glycated hemoglobin A1c (HbA1c), fasting plasma glucose, and weight. Results: Treatment failure rates were similar for empagliflozin and linagliptin vs placebo in adolescents, but significantly reduced with empagliflozin in young adults ( Conclusion: Empagliflozin reduced HbA1c in adolescents and young adults; however, these results highlight the challenges of monotherapy for youth with T2D and need for further studies.
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