Evidence map›Paper›PMID 40585986›Full record

ArticleTheranostics2025

OTUD1 inhibits osteoclast differentiation and osteoclastic bone loss through deubiquitinating and stabilizing PRDX1.

Xiaoyu Sun, Tong Wu, Shuhong Chen, Zheyu Zhao, Ruiwei Jia, Jun Ma, Lei Yin, Xingbei Pan, Yifan Ping, Yixin Mao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaoyu SunInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Tong WuInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Shuhong ChenInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Zheyu ZhaoInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Ruiwei JiaInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Jun MaInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Lei YinInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Xingbei PanInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yifan PingInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yixin MaoInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Lulu MaInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yilin MaInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Wu LuoChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Shengbin HuangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Guang LiangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bone ResorptionDeubiquitinating EnzymesOsteoclastsPeroxiredoxinsUbiquitin-Specific ProteasesAnimalsCell DifferentiationMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutOsteogenesisOsteoporosisRAW 264.7 CellsUbiquitinationDeubiquitinating EnzymesPeroxiredoxinsPrdx1 protein, mouseUbiquitin-Specific ProteasesDeubiquitinationMitochondrial dysfunctionOsteoclast differentiationOTUD1PRDX1

Identifiers

PMID40585986
PMCPMC12203675

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.