ArticleJournal of oral biology and craniofacial research
Natural biomaterial approach: Synergistic effects of cocoa and aloe vera in hydrogel-based bone regeneration: An in vitro study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To determine the characterization of cacao and aloe vera as natural hydrogel materials. Materials and methods: Natural hydrogel includes fermentation of cacao beans for 5 days, grinding into a paste, and separating cacao butter. Aloe vera extract was obtained through the maceration method with 70 % ethanol. Samples were divided into four groups with different concentrations and sterilized using gamma radiation. Tests included a porosity test using the liquid displacement method, a biodegradability test with PBS pH 7.4, a viscosity test using a Stormer viscometer, and an antibacterial test against Results: The hydrogel porosity of the four groups was within the ideal range for bone regeneration (75-86 % ± 0.02) without significant differences. Hydrogel with aloe vera content of 12.5 mg/ml showed the highest degradation on days 1 (65.1 % ± 1.01), day 7 (49.56 % ± 3.58), and day 14 (77.91 % ± 5.15). The higher the aloe vera content, the lower the viscosity of the hydrogel. Aloe vera-cocoa hydrogel has antibacterial properties that can inhibit the growth of A. actinomycetemcomitans bacteria, with effectiveness starting from a concentration of 3.125 mg/ml. Conclusion: Hydrogel of aloe vera - alkalized cacao demonstrates optimal porosity, biodegradability, and viscosity, which can be a candidate for socket preservation material to prevent alveolar bone resorption after tooth extraction. Clinical significance: Alkalized aloe vera-cocoa hydrogel can be a promising alternative socket preservation material after tooth extraction. This material has optimal porosity, controlled biodegradability, suitable viscosity, and antibacterial activity, thus potentially preventing alveolar bone resorption in a more economical and biocompatible manner.
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