Evidence map›Paper›PMID 40586157›Full record

ArticleJournal of cosmetic dermatology2025

Examining the Relationship Between Alopecia Areata and Mental Health: An Investigation of the Global Burden of Disease Study 2021.

Aditya K Gupta, Vasiliki Economopoulos, Mesbah Talukder

Abstract read
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aditya K GuptaDivision of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-8664-7723
Vasiliki EconomopoulosMediprobe Research Inc., London, Ontario, Canada.
Mesbah TalukderSchool of Pharmacy, BRAC University, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0003-0691-640X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlopecia areata (AA), an autoimmune hair loss disorder, can significantly alter a person's appearance and cause emotional distress. This disorder has been linked to anxiety and depression, but most work has been done on either one-population samples or has been conducted using heterogeneous populations, potentially skewing results.

aimsWe aim to obtain a better understanding of the relationship of AA with anxiety and depression in more finely divided populations based on sex, age, and country.

methodsWe have accessed data present on AA, anxiety and depressive disorders within the Global Burden of Disease Study 2021. We downloaded data from China, Japan, India, Brazil and the United States for males and females less than 20, 20 to 54 and 55 years of age and older. We extracted the prevalence and years lived with disability (YLDs) measures as surrogate markers for extent and severity of disease respectively. Pearson's correlation coefficient was calculated for both prevalence and YLDs for AA versus anxiety as well as for AA versus depression.

resultsWe found significant positive correlations of AA with anxiety and depression in females: primarily in China, Japan, India, and Brazil for anxiety, and China, India, and Brazil for depression. Additionally, significant correlations tended to occur in younger females.

conclusionsThis study demonstrates differences in the correlation of AA disease extent and severity with anxiety and depression between countries, sex, and age. This highlights the need for more finely detailed studies to truly determine the impact of AA on mental health globally.

Indexed as

Alopecia AreataAnxietyDepressionMental HealthAdultAge FactorsBrazilChinaFemaleGlobal Burden of DiseaseHumansIndiaJapanMaleMiddle AgedPrevalencealopecia areataglobal burden of disease study 2021mental health

Identifiers

PMID40586157
PMCPMC12207715

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.