Evidence map›Paper›PMID 40586226›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Dual-Crosslinked Betaine-Based Amphiphilic Hydrogel as a Promising Vitreous Substitute: Anti-Adhesion, Anti-Fouling, and Anti-Cell Proliferation.

Yuting Cai, Yun Tan, Jian Cao, Xiaoyuan Zhou, Xingyuan Li, Jianghua Li, Chuntai Liu, Yi Zhang, Yun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuting CaiDepartment of Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Yun TanHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Jian CaoJiangxi Province Division of National Clinical Research Center for Ocular Diseases, Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, 330006, China.
Xiaoyuan ZhouHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Xingyuan LiDepartment of Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Jianghua LiHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Chuntai LiuKey Laboratory of Materials Processing and Old Ministry of Education, Zhengzhou University, Zhengzhou, 50002, China.
Yi ZhangHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Yun LiDepartment of Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.ORCID https://orcid.org/0000-0001-8963-5819

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515110532Department of Science and Technology of Hunan Province 2019TP1001Health Research Project of Hunan Provincial Health Commission 202207022581National Natural Science Foundation of China 21972169National Natural Science Foundation of China 82171087Natural Science Foundation of Hunan Province 2023JJ70021
6 · The paper itself

Abstract

Developing an ideal vitreous substitute remains a significant challenge in ophthalmic surgery. This study introduces a novel dual-crosslinked betaine-based amphiphilic polymer hydrogel (BAPHs) synthesized via in situ free radical copolymerization. The resulting BAPHs exhibit tunable viscoelasticity, intrinsic self-healing property, injectability, stable micromorphology, and optical transparency, all modifiable by adjusting the chemical cross-linker content. When tested in a vitrectomized rabbit model, the BAPHs demonstrated optimal optical properties, mechanical stability, and promising biocompatibility. These results suggest that the BAPHs offer a transformative approach to vitreous substitution, with the potential to overcome the limitations of current clinical materials, offering both structural and functional benefits.

Indexed as

BetaineBiocompatible MaterialsCell ProliferationHydrogelsVitreous BodyAnimalsCell AdhesionCross-Linking ReagentsRabbitsBetaineBiocompatible MaterialsCross-Linking ReagentsHydrogelsamphiphilic polymerinjectable hydrogelsself‐assemblyvitreoretinopathyvitreous substitute

Identifiers

PMID40586226
PMCPMC12462983

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.