ArticleJournal of the American Geriatrics Society2025
Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.
Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Is Unilateral CT Measurement of the Vastus Intermedius Sufficient for Fall Risk Prediction in Older Adults?Geriatrics & gerontology international · 2026Article
- Should nasogastric enteral feeding become a standard escalation to reverse malnutrition in liver transplant candidates?Hepatobiliary surgery and nutrition · 2026Article
- Reply to Comment on: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.Journal of the American Geriatrics Society · 2026Article
- Association of computed tomography (CT)-derived muscle area and density at multiple sites with 10-year fracture risk in older men.JBMR plus · 2026Article
- Artificial intelligence-driven assessment of sarcopenia in orthopedic geriatrics: technical progress and clinical implications.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe automated segmentation of computed tomography (CT) images has made their opportunistic use more feasible, yet, the association of muscle area and density from multiple anatomical regions with functional outcomes and mortality risk in older adults has not been fully explored. We aimed to determine if muscle area and density at the L1 and L3 vertebra and right and left proximal thigh were similarly related to functional outcomes and 10-year mortality risk.
methodsMen from the Osteoporotic Fractures in Men (MrOS) study who had CT images, measures of grip strength, 6 m walking speed, and leg power (Nottingham Power Rig) at the baseline visit were included in the analyses (n = 3290, 73.7 ± 5.8 years). CT images were automatically segmented to derive muscle area and muscle density. Deaths were centrally adjudicated over a 10-year follow-up. Linear regression and proportional hazards were used to model relationships of CT muscle metrics with functional outcomes and mortality, respectively, while adjusting for covariates.
resultsMuscle area and density were positively related to functional outcomes regardless of anatomical region, with the most variance explained in leg power (adjusted R
conclusionAutomated measures of CT muscle area and density are related to functional outcomes and risk of mortality in older men, regardless of CT anatomical region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.