Evidence map›Paper›PMID 40586321›Full record

ReviewBriefings in bioinformatics2025

Computational modeling of single-cell dynamics data.

Wenbo Guo, Zeyu Chen, Jin Gu

Abstract readReview
In one paragraph

Review in Briefings in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wenbo GuoMOE Key Lab of Bioinformatics, BNRIST Bioinformatics Division, Department of Automation, Tsinghua University, No. 30 Shuangqing Road, Haidian District, Beijing 100084, China.
Zeyu Chen
Jin GuMOE Key Lab of Bioinformatics, BNRIST Bioinformatics Division, Department of Automation, Tsinghua University, No. 30 Shuangqing Road, Haidian District, Beijing 100084, China.

Funding

China Postdoctoral Science Foundation 2022 M721839National Key Research and Development Program of China 2020YFA0712403National Key Research and Development Program of China 2021YFF1200901National Natural Science Foundation of China 62133006National Natural Science Foundation of China 92268104
6 · The paper itself

Abstract

Deciphering the cell dynamics in complex biological systems is of great significance for understanding the mechanisms of life and facilitating disease treatment. Recent advances in single-cell sequencing technologies have enabled the measurement of single-cell characteristics over multiple time points. However, the integration and analysis of these dynamic single-cell data face many challenges and raise new demands for computational methodologies. In this review, we first elaborate these challenges in the context of experimental limitations, data features, and biological discoveries. Then, we provide an overview of the algorithmic advancements across four key tasks: inferring single-cell dynamics, dissecting dynamic mechanisms, predicting future cell fates, and integrating lineage tracing information to characterize cell dynamics. Finally, we discuss that the cutting-edge developments in biological technologies and artificial intelligence algorithms may greatly enhance our ability to explore complex life processes from a spatiotemporal systemic perspective.

Indexed as

Computational BiologyComputer SimulationModels, BiologicalSingle-Cell AnalysisAlgorithmsAnimalsHumansalgorithmsmachine learningsingle-cell dynamicstime-series data

Identifiers

PMID40586321
PMCPMC12207405

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.