Evidence map›Paper›PMID 40586367›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Metal-Responsive Up-Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding.

Keita Mori, Tsubura Kuramochi, Motonori Matsusaki, Yuki Hashiguchi, Masaki Okumura, Tomohide Saio, Yoshiaki Furukawa, Kenta Arai, Takahiro Muraoka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keita MoriDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.ORCID 0000-0003-3572-7384
Tsubura KuramochiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University 6-3 Aramaki-Aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Motonori MatsusakiInstitute of Advanced Medical Sciences, Tokushima University 3-18-5 Kuramoto-cho, Tokushima, 770-8503, Japan.
Yuki HashiguchiDepartment of Chemistry, Keio University 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa, 223-8522, Japan.
Masaki OkumuraFrontier Research Institute for Interdisciplinary Sciences, Tohoku University 6-3 Aramaki-Aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Tomohide SaioInstitute of Advanced Medical Sciences, Tokushima University 3-18-5 Kuramoto-cho, Tokushima, 770-8503, Japan.
Yoshiaki FurukawaDepartment of Chemistry, Keio University 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa, 223-8522, Japan.
Kenta AraiDepartment of Chemistry, School of Science, Tokai University 4-1-1 Kitakaname, Hiratsuka, Kanagawa, 259-1292, Japan.
Takahiro MuraokaDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.ORCID 0000-0001-6744-048X

Funding

Asahi Glass FoundationCanon FoundationG-7 Scholarship FoundationJSPS JP21H05094JSPS JP21H05095JSPS JP21H05096JSPS JP23KJ0851JSPS JP23KK0105JST JPMJCR19S4JST JPMJFR201FJST JPMJFR204WJST JPMJFR2122Kanagawa Institute of Industrial Science and Technology
6 · The paper itself

Abstract

The stress-responsive up-regulation process is a sophisticated biological response to maintain cellular homeostasis. In intracellular anti-oxidant systems, the expression level of oxidoreductases is up-regulated under oxidative stress, mitigating oxidative damage on biomolecules and enhancing protein folding capacity. Herein, inspired by the biological system, we developed a synthetic folding promotor whose reactivity is up-regulated under stress conditions. We conjugated two metal-binding 1,4,7,11-tetraazacyclotetradecane (cyclam) ligands and a redox-active disulfide to obtain cyclam-SS, whose reactivity can be enhanced under metal-induced stress. Metal coordination increased the redox potential of cyclam-SS, activating it as an oxidant. While Cu

Indexed as

CopperDisulfidesHeterocyclic CompoundsOxidative StressPeptidesProtein FoldingHeLa CellsHumansLigandsOxidation-ReductionProinsulinSuperoxide Dismutase-1Up-RegulationCoppercyclamDisulfidesHeterocyclic CompoundsLigandsPeptidesProinsulinSuperoxide Dismutase-1Copper ionsDisulfide bondsMetal‐induced stressOxidative foldingProtein folding

Identifiers

PMID40586367
PMCPMC12402870

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.