Evidence map›Paper›PMID 40586378›Full record

ArticleACS nano2025

Drug-Inspired Design of Supramolecular Polymers for Enhanced Drug Loading and Sustained Therapeutic Release.

Boran Sun, Mi-Kyung Shin, Meng Qin, Caleb F Anderson, Tian Xu, Jiarui Yang, Claire Sklar, Vsevolod Y Polotsky, Honggang Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Boran SunDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Mi-Kyung ShinDepartment of Anesthesiology and Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia 20037, United States.
Meng QinDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Caleb F AndersonDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Tian XuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Jiarui YangDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Claire SklarDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Vsevolod Y PolotskyDepartment of Anesthesiology and Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia 20037, United States.
Honggang CuiDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0002-4684-2655

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
NHLBI NIH HHS R01 HL133100
6 · The paper itself

Abstract

Supramolecular polymeric hydrogels have emerged as a dynamic, versatile platform for localized therapeutic delivery, leveraging reversible and tunable noncovalent interactions. Despite their potential, designing supramolecular polymers that combine high drug loading with sustained, controlled release remains a considerable challenge. Here, we introduce a series of drug-inspired, peptide-based monomers engineered as supramolecular hydrogelators to facilitate high-affinity coassembly with therapeutic agents. By strategically utilizing electrostatic complexation and π-π stacking interactions, these hydrogelators self-assemble into robust supramolecular polymer networks with well-defined nanostructures, achieving nearly 100% fingolimod loading efficiency and extremely high loading capacity (up to approximately 32% by mass). Our results demonstrate that these tailored supramolecular interactions not only enhance the fingolimod drug loading efficiency and capacity, but also modulate the self-assembly and dissociation process, enabling prolonged and predictable drug release both

Indexed as

Drug CarriersDrug DesignFingolimod HydrochloridePolymersAnimalsDelayed-Action PreparationsDrug LiberationHumansHydrogelsMacromolecular SubstancesMicePeptidesDelayed-Action PreparationsDrug CarriersFingolimod HydrochlorideHydrogelsMacromolecular SubstancesPeptidesPolymerscontrolled releasedrug deliveryfingolimodhydrogelshypertensionsupramolecular polymers

Identifiers

PMID40586378
PMCPMC12811758

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.