Evidence map›Paper›PMID 40586387›Full record

ReviewAging and disease2025

Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief.

Hong Wu, Jia-Yi Wu, Shao-Jie Gao, Lin Liu, Xin-Yi Dai, Wen-Lu Song, Long-Qing Zhang, Dai-Qiang Liu, Ying-Xin Tang, Ya-Qun Zhou and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hong WuDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jia-Yi WuDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Shao-Jie GaoDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lin LiuDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xin-Yi DaiDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wen-Lu SongDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Long-Qing ZhangDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Dai-Qiang LiuDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ying-Xin TangDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ya-Qun ZhouDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wei MeiDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol, a natural polyphenol with anti-inflammatory, antioxidant, and neuroprotective properties, shows great potential in managing chronic pain. This review explores its analgesic mechanisms, including the inhibition of neuroinflammation, enhancement of antioxidant activity, induction of autophagy, reduction of endoplasmic reticulum stress, modulation of the serotonin system, restoration of gut microbiota homeostasis, regulation of the neuroendocrine system, and promotion of mitochondrial biogenesis. While its analgesic potential is considerable, future research should prioritize enhancing its bioavailability, investigating drug interactions, and confirming long-term safety to develop more effective therapies for chronic pain.

Indexed as

AnalgesicsAntioxidantsChronic PainResveratrolAnimalsHumansAnalgesicsAntioxidantsResveratrol

Identifiers

PMID40586387
PMCPMC13256343

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.