Evidence map›Paper›PMID 40586906›Full record

ArticleCellular and molecular life sciences : CMLS2025

Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer.

Natalya Maluchenko, Alexandra Saulina, Olga Geraskina, Elena Kotova, Anna Korovina, Grigoriy Armeev, Mikhail Kirpichnikov, Alexey Feofanov, Vasily Studitsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Natalya Maluchenko *Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia. mal_nat@mail.ru.
Alexandra Saulina *Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Olga GeraskinaFaculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Elena KotovaFox Chase Cancer Center, Philadelphia, PA, 19111-2497, USA.
Anna KorovinaFaculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Grigoriy ArmeevFaculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Mikhail KirpichnikovFaculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Alexey FeofanovFaculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Vasily StuditskyFaculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia. vasily.studitsky@fccc.edu.ORCID http://orcid.org/0000-0002-7389-7993

Funding

Small-molecule exploitation of ZBP1-driven nuclear necroptosis for cancer immunotherapyR01CA269975 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI SIDDHARTH BALACHANDRAN, VASILY M STUDITSKY · 2023 to 2026
$3.0M
Foundation for the National Institutes of Health R01CA269975NCI NIH HHS R01 CA269975Russian Foundation for Fundamental Investigations 19-74-30003
6 · The paper itself

Abstract

Poly(ADP-ribose)polymerase 2 (PARP2) is a nuclear protein, DNA damage sensor and an emerging target for development of anti-cancer drugs. Previously it was discovered that PARP2 binds to nucleosomes; however, critical factors involved in this process remain unknown. We demonstrated that in the presence of Mg

Indexed as

NucleosomesPoly(ADP-ribose) PolymerasesZincBinding SitesCalciumDNA DamageHumansMagnesiumProtein BindingCalciumMagnesiumNucleosomesPARP2 protein, humanPoly(ADP-ribose) PolymerasesZincAutoPARylationEMSAMg2+PARP2SpFRET microscopyWGR domainZn2+

Identifiers

PMID40586906
PMCPMC12209172

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.