Evidence map›Paper›PMID 40588395›Full record

ArticleJournal of neurophysiology2025

Mechanisms involved in corticotropin-releasing factor-induced excitation of entorhinal neurons and facilitation of glutamate release at the perforant pathway.

Chidiebele S Oraegbuna, Lalitha Kurada, Huiming Li, Saobo Lei

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chidiebele S OraegbunaDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States.ORCID 0009-0004-4459-5365
Lalitha KuradaDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States.
Huiming LiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States.
Saobo LeiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States.ORCID 0000-0002-3882-0253

Funding

Cellular and molecular mechanisms of vasopressin in anxietyR01MH118258 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI LEI, SAOBO · 2019 to 2023
$1.5M
HHS | NIH | National Institute of Mental Health (NIMH) R01MH118258NIMH NIH HHS R01 MH118258
6 · The paper itself

Abstract

The entorhinal cortex (EC) is closely related to emotional control, consolidation and recall of memories, Alzheimer's disease, schizophrenia, and temporal lobe epilepsy. Corticotropin-releasing factor (CRF) is also implicated in these physiological functions and pathological disorders. Although both CRF peptide and CRF

Indexed as

Corticotropin-Releasing HormoneEntorhinal CortexGlutamic AcidNeuronsPerforant PathwayAnimalsCyclic AMPHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMaleMiceMice, Inbred C57BLRatsRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneCorticotropin-Releasing HormoneCRF receptor type 2Cyclic AMPGlutamic AcidHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsReceptors, Corticotropin-Releasing Hormoneaction potentialexcitabilityG proteinion channelpeptide

Identifiers

PMID40588395
PMCPMC12306183

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.