Evidence map›Paper›PMID 40588398›Full record

ArticleJournal of medical genetics2025

Evaluation of whole-body MRI for cancer early detection in Li-Fraumeni syndrome.

Peter Sodde, Zerin Hyder, Sarah Pugh, Fiona Lalloo, Richard Martin, Calvin Soh, Jawad Naqvi, Richard Whitehouse, D Gareth Evans, Emma Roisin Woodward

Abstract read
In one paragraph

Article in Journal of medical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peter SoddeDivision of Cancer Sciences, Faculty of Medicine, Biology and Health Sciences, The University of Manchester, Manchester, UK peter.sodde@manchester.ac.uk.ORCID http://orcid.org/0000-0003-2209-5875
Zerin HyderManchester Centre for Genomic Medicine (MCGM), Manchester University Foundation Trust, Manchester, UK.
Sarah PughManchester Centre for Genomic Medicine (MCGM), Manchester University Foundation Trust, Manchester, UK.
Fiona LallooManchester Centre for Genomic Medicine (MCGM), Manchester University Foundation Trust, Manchester, UK.
Richard MartinCentre for Life, Newcastle upon Tyne, UK.
Calvin SohDepartment of Radiology, Manchester University Foundation Trust, Manchester, UK.
Jawad NaqviDepartment of Radiology, Manchester University Foundation Trust, Manchester, UK.
Richard WhitehouseDepartment of Radiology, Manchester University Foundation Trust, Manchester, UK.
D Gareth EvansManchester Centre for Genomic Medicine (MCGM), Manchester University Foundation Trust, Manchester, UK.
Emma Roisin WoodwardDivision of Cancer Sciences, Faculty of Medicine, Biology and Health Sciences, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-6297-2855

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Li-Fraumeni syndrome (LFS) is a high-risk hereditary cancer predisposition syndrome affecting 1 in 5000 individuals. Current standard of care in adults includes annual whole-body MRI (WB-MRI) and MRI brain (MRB) surveillance to enable early cancer detection. We performed a retrospective single-centre study of adults with

Indexed as

Early Detection of CancerLi-Fraumeni SyndromeMagnetic Resonance ImagingNeoplasmsWhole Body ImagingAdultAgedFemaleGenetic Predisposition to DiseaseGerm-Line MutationHumansMaleMiddle AgedRetrospective StudiesTumor Suppressor Protein p53Young AdultTP53 protein, humanTumor Suppressor Protein p53Early DiagnosisHeredity

Identifiers

PMID40588398
PMCPMC12505049

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.