Evidence map›Paper›PMID 40588756›Full record

ArticleThyroid research2025

Preconception thyroid function in relation to pregnancy lipids among women attending a fertility center.

Xilin Shen, Tim I M Korevaar, Tamarra James-Todd, Paige L Williams, Jennifer B Ford, Dan Zhang, Maarten A Broeren, Kathryn M Rexrode, Russ Hauser, Jorge E Chavarro and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xilin ShenKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Tim I M KorevaarDepartment of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus University Medical Center, Rotterdam, Netherlands.
Tamarra James-ToddDepartments of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA.
Paige L WilliamsEpidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
Jennifer B FordDepartments of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA.
Dan ZhangKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Maarten A BroerenLaboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, Netherlands.
Kathryn M RexrodeDepartment of Medicine, Division of Women's Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Russ HauserDepartments of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA.
Jorge E ChavarroDepartments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA.
Lidia Mínguez-AlarcónDepartments of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA. lminguez@hsph.harvard.edu.
Earth Study Team

Funding

Maternal and Paternal Flame Retardant Exposure, Impact on Fertility and PregnancyR01ES022955 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B, MEEKER, JOHN D. · 2014 to 2018
$2.9M
Male pesticide exposure, reproductive health and epigeneticsR01ES034700 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Lidia Minguez Alarcon · 2023 to 2026
$2.7M
NIEHS NIH HHS R01 ES022955NIEHS NIH HHS R01ES022955NIEHS NIH HHS R01 ES034700NIEHS NIH HHS R01ES034700
6 · The paper itself

Abstract

contextThyroid hormones play an essential role in lipid metabolism. The association of thyroid function and dyslipidemia in women has been mostly studied in the general population, and epidemiological evidence during pregnancy is scarce.

objectiveWe investigated the association of preconception thyroid function and autoimmunity with serum lipid biomarkers during pregnancy among 142 pregnant women enrolled in the Environment and Reproductive Health (EARTH) Study (2005 - 2017) who were seeking treatment at a fertility center.

methodsBefore conception, we measured biomarkers of thyroid function and autoimmunity including thyroid stimulating hormone (TSH), free thyroxine (fT

resultsWe observed a negative association between preconception serum TT

conclusionsThis study showed that some preconception biomarkers of thyroid function were associated with serum lipid levels during pregnancy. These results highlight the importance of thyroid function during the preconception window, and its potential impact on cholesterol levels at different time periods in the pregnancy.

Indexed as

DyslipidemiaPregnancy lipid levelThyroid hormones

Identifiers

PMID40588756
PMCPMC12211867

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.