Evidence map›Paper›PMID 40589476›Full record

ArticleNeuroprotection (Chichester, England)2025

Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases.

Tobiloba S Olajide, Omamuyovwi M Ijomone

Abstract read
In one paragraph

Article in Neuroprotection (Chichester, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Differential Binding of ΔFN3 Proteins ofInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Frontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tobiloba S OlajideLaboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo, Nigeria.ORCID 0000-0001-7234-3748
Omamuyovwi M IjomoneLaboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo, Nigeria.ORCID 0000-0002-0933-8409

Funding

Developmental neurotoxicity and autism spectrum disorderK43TW011920 · FIC · UNIVERSITY OF MEDICAL SCIENCES, ONDO · PI Omamuyovwi Meashack Ijomone · 2022 to 2026
$500k
FIC NIH HHS K43 TW011920
6 · The paper itself

Abstract

Recent evidence suggests a more important role of the gut microbiota in neurodegenerative diseases (NDDs) given its relationship through the microbiota-gut-brain as an active communication system aiding in maintaining homeostasis between the brain and the gut. This review focuses on how modulation of gut microbiota can serves as a therapeutic strategy for NDDs, emphasizing the neuroprotective effects of probiotics. Probiotics are live microorganisms that confer health benefits, and their interaction with gut-microbiota influences neurogenesis, neurotransmitter regulation, and neuroinflammation. Recent advancements, including germ-free animal models, fecal microbiota transplantation (FMT), and diverse probiotic strains, have revealed the underlying mechanisms linking gut health to brain function. Notably, several

Indexed as

gut microbiotamicrobiota-gut-brainneurodenegenerative diseasesneurogenesisprobiotics

Identifiers

PMID40589476
PMCPMC12208687

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.