ReviewJournal of the Saudi Heart Association2025
Assessment of the Relationship Between Serum Vitamin D Level and Its Cardiovascular Outcomes: A Systematic Review and Meta-analysis Study.
Review in Journal of the Saudi Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Associations of vitamin D with coronary revascularization and heart rate variability in hypertensive patients.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cardiovascular events are the most common cause of mortality worldwide. Various studies have shown the relationship between serum 25-hydroxyvitamin D [25(OH)Vit D] levels and cardiovascular events. The purpose of this study is to investigate the meta-analysis of the relationship between serum 25(OH)Vit D levels and the risk of cardiovascular diseases (CVD), including stroke, coronary heart disease, peripheral arterial disease, and aortic disease in the population. Method: Using valid keywords and searching the Medline, Science Direct, Scopus, and Web of Science databases, 22 papers were compiled. Data analysis was performed in the group of people with low serum 25(OH)Vit D levels (<75 nmol/L). The data were analyzed using a random-effects meta-analysis model with R and Stata Version 17.0 software. Results: In this study, 22 papers were included. This meta-analysis of 12 cohort studies (n = 39,396) found that lower serum vitamin D levels were significantly associated with increased risk of cardiovascular disease (HR = 1.38, 95 % CI: 1.24-1.53) and all-cause mortality (HR = 1.64, 95 % CI: 1.33-2.03). Dose-response analysis showed that each 10 nmol/L increase in vitamin D reduced CVD risk by 8.2 % (HR = 0.992, 95 % CI: 0.990-0.993). A non-linear inverse association was observed for all-cause mortality, with stronger protective effects at lower vitamin D levels. These results, in addition to most of the studies included in the systematic review, support a potential protective role of higher vitamin D concentrations. Conclusion: The results of this study showed a relationship between serum 25(OH)Vit D levels and cardiovascular outcomes; the lower the serum 25(OH)Vit D level, the higher the risk of cardiovascular disease.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.