Evidence map›Paper›PMID 40589795›Full record

ArticleJournal of substance use2025

Prenatal opioid exposure and the early life epigenome: results from ECHO.

Rose Schrott, Henri Garrison-Desany, Lyndsay Avalos, Carrie V Breton, Dana M Dabelea, Karen Derefinko, Anne Dunlop, Fang Fang, Abigail Gaylord, Torie Grant and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of substance use, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Rose SchrottWendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Henri Garrison-DesanyDepartment of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States.
Lyndsay AvalosDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Carrie V BretonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Dana M DabeleaLifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Karen DerefinkoDepartment of Preventive Medicine and Department of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Anne DunlopDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.
Fang FangRTI International, Research Triangle Park, Durham, North Carolina, USA.
Abigail GaylordDepartment of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, New York, USA.
Torie GrantDepartment of Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore,United States.
Marie-France HivertDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Anna K KnightDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.
Barry LesterDepartments of Psychiatry and Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Kristen LyallAJ Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania, USA.
Cindy McEvoyDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA.
Ruby NguyenDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Grier PageRTI International, Research Triangle Park, Durham, North Carolina, USA.
Alison PaquetteDepartment of Pediatrics, School of Medicine, University of Washington, Seattle, Washington, USA.
Douglas RudenDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, United States.
Lyndsey E Shorey-KendrickDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States.
Alicia K SmithDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.
Eliot SpindelDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States.
Heather E VolkWendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Christine Ladd-AcostaWendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Linda S Adair, Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Understanding Breastfeeding Practices Among ECHO Cohort Participants Before and During/After the COVID-19 PandemicUH3OD023285 · OD · MICHIGAN STATE UNIVERSITY · PI Charles James Barone, MICHAEL R. ELLIOTT · 2018 to 2026
$24.5M
ENVIRONMENTAL INFLUENCES ON NEURODEVELOPMENTAL OUTCOME IN INFANTS BORN VERY PRETERMUH3OD023347 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., MARSIT, CARMEN JOSEPH · 2018 to 2022
$18.4M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUH3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI Traci Allison Bekelman, Dana Dabelea · 2018 to 2026
$14.8M
Trajectories and Environments in Autism: a Multi-cohort Study (TEAMS) following autism families in ECHO Phase 2UH3OD023342 · OD · DREXEL UNIVERSITY · PI KRISTEN Lyall, HEATHER E VOLK · 2018 to 2026
$12.8M
NIAID NIH HHS K23 AI159144NIEHS NIH HHS P30 ES007033NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UH3 OD023248NIH HHS UH3 OD023271NIH HHS UH3 OD023275NIH HHS UH3 OD023285NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023288NIH HHS UH3 OD023305NIH HHS UH3 OD023318NIH HHS UH3 OD023342NIH HHS UH3 OD023347NIMH NIH HHS T32 MH014592
6 · The paper itself

Abstract

Background: Prenatal opioid exposure has been associated with adverse child health outcomes. Changes to the epigenome provide a plausible mechanism through which effects may be elicited. We investigated whether prenatal opioid exposure was associated with locus-specific changes in umbilical cord blood DNA methylation (DNAm) and gestational epigenetic age. Methods: We leveraged data from the Environmental influences on Child Health Outcomes cohort. Prenatal opioid data was obtained from maternal self-report and/or medical record data. DNAm measures were generated from blood biospecimens collected at birth. Linear regression models tested associations between prenatal maternal opioid exposure and epigenetic outcomes in crude and fully adjusted models. Results: We tested the association between prenatal opioid exposure and cord blood DNAm at 15 CpG sites in 385 ( Conclusions: We identified a nominally significant association between prenatal opioid exposure and DNAm at one CpG site. Future studies should continue investigating the effect of this exposure on the epigenome.

Indexed as

DNA methylationepigeneticsopioidsprenatal

Identifiers

PMID40589795
PMCPMC12208659

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.