ArticleInternational journal of general medicine2025
Expression Significance and Relationship of Serum miR-542-3p and lncRNA TUG1 in STBI Patients and Their Predictive Value for Prognosis.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- lncRNAInternational journal of molecular medicine · 2026Article
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6 authors.
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Abstract
Objective: Analysis of the Expression Significance and Relationship of Serum MicroRNA-542-3p (miR-542-3p) and Long Non-Coding RNA Taurine Upregulated Gene 1 (lncRNA TUG1) in Patients with Severe Traumatic Brain Injury (STBI) and Their Predictive Value for Prognosis. Methods: A retrospective analysis was conducted on 193 TBI patients, including 95 STBI (Group A) and 98 non-STBI (Group B) cases. Serum miR-542-3p and lncRNA TUG1 levels were measured upon admission. STBI patients were followed for 6 months and divided into good or poor prognosis groups. Logistic regression, correlation analyses, and ROC curves were used to assess prognostic factors and diagnostic performance. Results: Compared to Group B, Group A patients had significantly lower serum miR-542-3p levels and higher lncRNA TUG1 levels (P < 0.05). A negative correlation was observed between miR-542-3p and lncRNA TUG1 (r = -0.607, P < 0.001). Among STBI patients, 33 (34.74%) had poor prognosis. Brain herniation, brainstem injury, hypoalbuminemia, and high lncRNA TUG1 were identified as independent risk factors, while high miR-542-3p was a protective factor (P < 0.05). Additionally, miR-542-3p levels were negatively correlated with poor prognosis (r = -0.643), while lncRNA TUG1 showed a positive correlation (r = 0.621). ROC analysis showed AUCs of 0.846 for miR-542-3p, 0.823 for lncRNA TUG1, and 0.925 for their combination, indicating improved predictive accuracy with combined detection. Conclusion: miR-542-3p is downregulated and lncRNA TUG1 upregulated in STBI. Both are significantly correlated with prognosis and offer strong predictive value, especially when combined.
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