Evidence map›Paper›PMID 40590126›Full record

ArticleCirculation research2025

CEMIP Maintains Vascular Contractility by Controlling PP1c-MLC20 Cascade in SMCs.

Ze Yuan, Qi Li, Xue Bai, Kai Zhang, Jinlong He, Ding Ai, Qinghua Cui, Yi Zhu, Bochuan Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ze YuanThe Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics (Z.Y., J.H., D.A., Y.Z., B.L.), Tianjin Medical University, China.
Qi LiPanzhihua Central Hospital, Sichuan, China (Q.L.).
Xue BaiDepartment of Biochemistry and Molecular Biology (X.B., K.Z.), Tianjin Medical University, China.
Kai ZhangDepartment of Biochemistry and Molecular Biology (X.B., K.Z.), Tianjin Medical University, China.ORCID 0000-0003-2800-0531
Jinlong HeThe Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics (Z.Y., J.H., D.A., Y.Z., B.L.), Tianjin Medical University, China.ORCID 0000-0001-7349-8135
Ding AiThe Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics (Z.Y., J.H., D.A., Y.Z., B.L.), Tianjin Medical University, China.ORCID 0000-0001-5992-9904
Qinghua CuiDepartment of Biomedical Informatics, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China (Q.C.).ORCID 0000-0003-3018-5221
Yi ZhuThe Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics (Z.Y., J.H., D.A., Y.Z., B.L.), Tianjin Medical University, China.ORCID 0000-0001-7725-9166
Bochuan LiThe Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics (Z.Y., J.H., D.A., Y.Z., B.L.), Tianjin Medical University, China.ORCID 0000-0003-1670-2077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe CEMIP (cell migration-inducing protein) exhibits extremely high expression levels in smooth muscle tissues. However, whether CEMIP modulates the contractile phenotype of vascular smooth muscle cells and confers blood pressure remains elusive.

methodsTo explore the role of CEMIP in SMCs, we generated a mouse model with SMC-specific CEMIP deficiency (SMC-

resultsCEMIP is abundantly expressed in smooth muscle tissues including the mesenteric artery, aorta, and intestine. In a serum-starved contractile phenotype, SMCs responded to serum stimulation by gradually decreasing CEMIP expression, as they shifted to a secretory phenotype. The mice lacking CEMIP in SMCs showed significantly reduced contractility and blood pressure compared with their counterparts of age-matched wild-type littermates (

conclusionsCEMIP functions as a gatekeeper for maintaining the contractile phenotype of SMCs via the PP1c-MLC20 cascade. CEMIP is indispensable for maintaining blood pressure.

Indexed as

Muscle, Smooth, VascularMyocytes, Smooth MuscleMyosin Light ChainsProtein Phosphatase 1VasoconstrictionAnimalsBlood PressureCells, CulturedHumansMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionMyosin Light ChainsProtein Phosphatase 1blood pressuremuscle, smoothmyosin light chains

Identifiers

PMID40590126
PMCPMC12316136

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.