Evidence map›Paper›PMID 40590748›Full record

ReviewDiabetes technology & therapeutics2025

Practical Considerations and Implementation of Automated Insulin Delivery Systems.

Laurel H Messer, Gregory P Forlenza, Linda Gonder-Frederick, Korey Hood, Osagie Ebekozien, Katharine Barnard-Kelly, Lori M Laffel, Jennifer L Sherr, Rayhan Lal, Stuart A Weinzimer

Abstract readReview
In one paragraph

Review in Diabetes technology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laurel H MesserBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-7493-0989
Gregory P ForlenzaBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-3607-9788
Linda Gonder-FrederickCenter for Diabetes Technology, University of Virginia, USA.
Korey HoodDivision of Endocrinology, Department of Pediatrics, Stanford University, Stanford, California, USA.ORCID 0000-0001-5730-7749
Osagie EbekozienT1D Exchange, Boston, Massachusetts, USA.ORCID 0000-0002-8473-249X
Katharine Barnard-KellySouthern Health NHS Foundation Trust, Southampton, UK.ORCID 0000-0002-3888-3123
Lori M LaffelJoslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9675-3001
Jennifer L SherrDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-9301-3043
Rayhan LalDivision of Endocrinology, Department of Pediatrics, Stanford University, Stanford, California, USA.ORCID 0000-0002-8055-944X
Stuart A WeinzimerDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-7768-5189

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
The Optimal Pathway to Implanted Autonomous Insulin DeliveryK23DK122017 · NIDDK · STANFORD UNIVERSITY · PI LAL, RAYHAN · 2020 to 2024
$958k
NIDDK NIH HHS K23 DK122017NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK116074
6 · The paper itself

Abstract

Automated Insulin Delivery (AID) is in a new era of implementation challenges and opportunities for people with diabetes (PWD) and healthcare providers (HCPs). Beyond technologic variation, cost, access, and HCP endorsement/experience lead to uneven uptake of AID technologies, and attenuate universal ease of use. For AID to be broadly implemented, we must prioritize the lived experience for PWD, and consider how to alleviate burden to promote holistic wellbeing. Expectations and education help HCPs and PWD navigate the similarities and differences between AID devices, and help find common ties: users need to give the system time to work, learn to trust it, and not try to "trick" the system. Despite these learnings, disparities in uptake exist, both in clinical trials and in routine clinical care. Strategies to proactively address AID disparities are needed at multiple levels, all of which increase in importance as AID becomes more common for people with type 2 diabetes. Further, broader implementation will require comprehensive healthcare system integration efforts, including new data solutions. Overall, the success of AID requires ongoing transformation of clinical paradigms, with lockstep alignment between PWD and their families, healthcare professionals, researchers, funders, policy makers, and industry partners.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Hypoglycemic AgentsInsulinInsulin Infusion SystemsHealth PersonnelHumansHypoglycemic AgentsInsulinautomated insulin deliverydiabetes educationdisparitieshuman–machine interaction

Identifiers

PMID40590748
PMCPMC12915492

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.