ArticleAIDS (London, England)2025
Subpopulations with frequent healthcare barriers have increased risk of sexually transmitted infections and dropping out from HIV preexposure prophylaxis care.
Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Trial
- Characterising individuals with newly diagnosed HIV before versus during the era of PrEP: a descriptive time-series analysis of data from a sexual health centre in Amsterdam, the Netherlands, 2015 to 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Estimating the HIV PrEP care continuum among gay, bisexual and other men who have sex with men in Amsterdam and the Netherlands.AIDS (London, England) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCertain subpopulations (i.e., <25 years, transgender, sex worker, uninsured or migrant) were prioritized for inclusion in the Dutch preexposure prophylaxis (PrEP) pilot. We compared incidence of sexually transmitted infections (STI) during and drop-out from HIV PrEP care between prioritized and nonprioritized subpopulations.
designRetrospective longitudinal study using routinely collected data at the Centre for Sexual Health Amsterdam, 2019-2024.
methodsWe modelled incidence rates (IR) for any STI while on PrEP using Poisson regression, adjusting for testing frequency and calendar time. We modelled the probability of early loss-to-follow-up (LTFU) (i.e., no PrEP follow-up visit within 12 months of enrolment) using logistic regression, adjusting for sexual behaviour. We modelled the probability of later LTFU (i.e., no PrEP visit within 12 months of a prior PrEP follow-up visit) using competing risk regression, adjusting for sexual behaviour. We added subpopulations as indicator variables to all models to compare endpoints between groups.
resultsOf 4781 individuals included (median age 32 years, IQR = 26-40), 50.2% ( n = 2402) belonged to prioritized subpopulations. The IR of any STI was 101.6/100 person-years. STI IR were higher among those belonging to prioritized groups (except for the transgender group). 494 individuals had early LTFU, which was associated with age <25 years, reporting sex work, and being a migrant. Later LTFU occurred 933 times and was associated with age <25 years, being transgender, and reporting sex work.
conclusionPeople belonging to prioritized subpopulations had more STIs and were more often LTFU from PrEP care. Targeted interventions to support PrEP retention and prevent STIs are needed.
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