Evidence map›Paper›PMID 40591021›Full record

ArticleDiscover oncology2025

Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004-2024).

Yu Chen, Yuxuan Dai, Xing Wang, Jian Liu

Abstract read
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu Chen *Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310016, Zhejiang, China.
Yuxuan Dai *Department of Plastic Surgery, Beilun Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Ningbo, Zhejiang, China.
Xing Wang *Department of Head Neck Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
Jian LiuDepartment of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310016, Zhejiang, China. liujianzy@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to qualitatively and quantitatively assess the research landscape of palmitoylation in oncology using bibliometric analysis, thereby providing insights into research hotspots and emerging trends.

methodsThe data were sourced from the Web of Science Core Collection, retrieved using predefined search terms, and comprise review articles and original research papers published in English from 2004 to 2024. Bibliometric analysis and data visualization were performed using VOSviewer, CiteSpace, and Microsoft Excel.

resultsThe United States and China are the leading contributors to research in this field, with Shanghai Jiao Tong University being the most prolific institution in terms of publication output. Current research hotspots in protein palmitoylation related to oncology primarily encompass the enzymatic mechanisms and dynamic regulation of palmitoylation, palmitoylation-mediated lipid metabolic reprogramming and tumorigenesis, palmitoylation-mediated tumor signaling pathways, and targeted cancer therapy strategies based on palmitoylation modification. Current research trends primarily focus on the modulation of critical enzymes and signaling pathways, which influence tumor biology and prognosis. Additionally, emphasis is placed on metabolic reprogramming mediated by protein palmitoylation within the tumor microenvironment, especially regarding its role in tumor responsiveness to chemotherapy and immunotherapy.

conclusionThis study provides a comprehensive overview of recent advancements in research regarding protein palmitoylation modifications within oncology.

Indexed as

BibliometricsCancerImmunotherapyMetabolic reprogrammingPalmitoylation

Identifiers

PMID40591021
PMCPMC12214078

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.