Evidence map›Paper›PMID 40591113›Full record

ReviewDiscover oncology2025

Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors.

Menghan Gui, Xinmei Zheng, Hexin Fu, Mingming Cang, Haokai Ma, Jingshu He, Dong Tang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Menghan Gui *Yangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, China. 1807868893@qq.com.
Xinmei Zheng *Yangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, China.
Hexin FuYangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, China.
Mingming CangYangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, China.
Haokai MaXuzhou Medical University, Northern Jiangsu People's Hospital Affiliated to Xuzhou Medical University, Xuzhou, 225000, China.
Jingshu HeClinical Teaching Hospital of Medicine School, Nanjing University, Northern Jiangsu People's Hospital, Yangzhou, 225000, China.
Dong TangDepartment of General Surgery, Institute of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98, West Nantong Road, Guangling District, Yangzhou City, 225000, China. 83392785@qq.com.ORCID http://orcid.org/0009-0009-6687-3617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In gastrointestinal tumor treatment, conventional therapies are often limited by challenges such as tumor heterogeneity, high invasiveness, and recurrence rat. In recent years, sonodynamic therapy (SDT) has emerged as a promising alternative, leveraging sonosensitizers and ultrasound to disrupt cancer cells through microbubble vibrations, singlet oxygen generation, and immunogenic cell death. SDT also inhibits tumor vasculature and angiogenesis, enhancing its efficacy. However, the clinical application of SDT is currently hindered by limitations, such as poor water solubility and susceptibility to hypoxic tumor environments. Nanomaterial carriers, such as zeolitic imidazolate frameworks (ZIF-8), address these issues by targeting reactive oxygen species release and activating chemotherapeutic agents like tirapazamine (TPZ), improving therapeutic outcomes and safety. This review explores the fundamental principles of SDT, its integration with nanomaterials, and future directions in gastrointestinal tumor treatment.

Indexed as

Combination therapyGastrointestinal tumorsImmunotherapyNanomaterialsSonodynamic therapySonosensitizers

Identifiers

PMID40591113
PMCPMC12214208

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.