ArticleDigestive diseases and sciences2025
Severe Acute Pancreatitis-Associated Lung Injury: A Comprehensive Quadruple Analysis of Animal Models.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Plants and Plant-Derived Compounds Mediate Protection Across Diverse Pathological Conditions by Targeting the PANoptosis Pathways.Phytotherapy research : PTR · 2026Review
- Post-translational modification crosstalk in acute pancreatitis: linking acinar stress to innate immune amplification and tissue repair.Frontiers in immunology · 2026Review
- Demystifying anti-inflammatory therapeutic strategies against pancreatitis and concomitant diseases: a 2025 perspective.Theranostics · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundSevere acute pancreatitis (SAP) is a common clinical acute abdominal disorder. One of the critical complications of SAP is acute lung injury (ALI), which is the leading cause of high mortality in SAP patients. Establishing an animal model is pivotal in understanding of SAP pathogenesis and treatment.
methodsThe 5% Sodium taurocholate (STC) solution was administered to induce severe acute pancreatitis-associated acute lung injury (SAP-ALI). Additionally, a Sham operation group (SO) and a Normal saline control group (NS) were included in the study. Nine time-point subgroups were established at 3, 6, 9, 12, 18, 24, 36, 48, and 72 h post-treatment. Lung injury was comprehensively assessed from four perspectives: physiological dysfunction, inflammatory response, alterations in vascular permeability, and tissue damage. Ultimately, the model was constructed according to the previously established methodology. High-resolution micro-computed tomography (micro-CT) for small animals was employed to evaluate the extent of lung injury.
resultsThe SAP-ALI animal model was effectively induced using a 5% sodium taurocholate solution, with the peak lung injury score observed at 24 h post-induction. Histological examination of the entire pancreas in the micro-CT group revealed more pronounced pancreatic injury in the pancreatic head region at the 24-h time point following model establishment. Upon horizontal comparison of the micro-CT images with the complete lung pathology images, a close correlation between the injury sites was observed.
conclusionsAt the 24-h time point in the SAP animal model, the lung injury manifestations and diverse indicators were notably robust. The application of micro-CT emerged as a pivotal non-invasive modality for diagnosing lung injury in SAP-ALI animal models.
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