ArticleNeuron2025
A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Impact of Sema3A Interference on Cerebellum-Dependent Motor Associative Learning and Memory.International journal of molecular sciences · 2026Article
- Robust PHP in Adult Hippocampus: Essential Assay Optimizations.bioRxiv : the preprint server for biology · 2026Article
- Persistent adaptation through dual-timescale regulation of ion channel properties.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Persistent Adaptation through Dual-Timescale Regulation of Ion Channel Properties.bioRxiv : the preprint server for biology · 2025Article
- Establishing a continuum of cell types in the visual cortex.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Presynaptic homeostatic plasticity (PHP) is a potent form of adaptive plasticity that has been documented at synapses as diverse as the glutamatergic Drosophila neuromuscular junction (NMJ), cholinergic mammalian NMJ (including human), and glutamatergic synapses in the mammalian brain. We define secreted class III semaphorin as a unifying, trans-synaptic signal necessary for PHP at highly divergent synapses. Sema3a drives the rapid induction of PHP at the cholinergic mouse NMJ and synapses in the adult hippocampus (CA1), including cross-modal potentiation of inhibitory transmission. Three-dimensional electron microscopy (EM) reveals Sema3a-dependent active zone expansion, presynaptic stabilization, and the maintenance of synapse organization during PHP. Mechanistically, Sema3a promotes vesicle redistribution from a non-releasing to recycling and readily releasable vesicle pool. Finally, presynaptic-signal transduction is also commonly deployed, requiring activation of PlexinA4 and an integrin beta-1 (ITGB1) co-receptor. The widespread utilization of common PHP mechanisms emphasizes the translational potential of model organisms toward promoting neuronal resilience to combat brain disorders and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.