ReviewPharmacological research2025
Differential roles of individual bile acid in physiology and disease.
Review in Pharmacological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Bile acid signaling in health and disease.Molecular biomedicine · 2026Review
- Effects of Hedan Tablets Combined With Simvastatin on Hyperlipidemia: Insights From Microbiomics and Metabolomics.Biomedical chromatography : BMC · 2026Article
- Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights.Pharmacological research · 2026Article
- Bile Acid Metabolism Regulates Ovarian Function: Networks and Reproductive Health Applications.Expert reviews in molecular medicine · 2026Review
- Beyond Discrete Diagnoses: Conceptualizing Obesity-associated Metabolic Disorders as a Unified, Dynamic Continuum.Current obesity reports · 2025Review
- Dysregulated bile acid metabolism as a novel player in gout progression: emerging therapeutic strategies.Frontiers in endocrinology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Bile acids (BAs) have originally been linked to nutrient digestion and absorption, however, emerging research underscores their pivotal role as signaling molecules in regulating multiple physiological and pathological processes. Alternations in BA levels and profiles are frequently observed in a variety of diseases, indicating their potential as either diagnostic markers or therapeutic targets or agents. In addition to the levels of BAs, the specific composition of BA species, such as primary vs. secondary BAs, conjugated vs. unconjugated BAs, and hydroxylated vs. non-hydroxylated BAs, plays a critical role in maintaining physiological balance and modulating disease pathogenesis. In this review, we highlight the association between 12alpha-hydroxylated (12α-OH) BAs and non-12α-OH BAs, as well as other BA modifications, with diverse diseases, including liver diseases, gastrointestinal conditions, metabolic syndromes, age-related neurological diseases, and cancers. While substantial progress has been made in elucidating the pleotropic role of BAs in disease mechanisms, the clinical translation of BAs as diagnostic markers or therapeutic targets or agents requires further validation and standardization. Ongoing discoveries in this dynamic field are paving the way for breakthroughs in both mechanistic insight and clinical translation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.