Evidence map›Paper›PMID 40592687›Full record

ReviewTrends in immunology2025

Plans within plans: post-transcriptional regulation governs macrophage responses.

Mackenzie H Smith, Roy R Parker, Kristin L Patrick, Edward M C Courvan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mackenzie H SmithDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Roy R ParkerDepartment of Biochemistry, University of Colorado, Boulder, CO, 80303, USA; Howard Hughes Medical Institute, University of Colorado, Boulder, CO, 80303, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, 80303, USA. Electronic address: roy.parker@colorado.edu.
Kristin L PatrickDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. Electronic address: kristin.patrick@vumc.org.
Edward M C CourvanDepartment of Biochemistry, University of Colorado, Boulder, CO, 80303, USA; Howard Hughes Medical Institute, University of Colorado, Boulder, CO, 80303, USA. Electronic address: edward.courvan@colorado.edu.

Funding

Pre-mRNA splicing regulation is critical for controlling macrophage activationR35GM133720 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kristin Leigh Patrick · 2019 to 2026
$3.3M
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM133720
6 · The paper itself

Abstract

Macrophages are sentinels and first responders of the innate immune system. By sensing danger signals, they initiate and amplify inflammatory and regenerative cascades to control appropriate responses to pathogens and tissue damage. Transcriptional activation of macrophage gene expression has been studied extensively, but macrophage responses also rely on regulation of mRNAs following transcription. In this review we discuss mechanisms of post-transcriptional regulation that alter macrophage gene expression programs in profound and sometimes surprising ways. We explore how these control nodes are layered to form complex and dynamic circuits, discuss their role in disease, and conclude by outlining opportunities for future study of post-transcriptional regulation in macrophages.

Indexed as

Gene Expression RegulationMacrophagesRNA Processing, Post-TranscriptionalAnimalsHumansImmunity, InnateMacrophage Activationinnate immune systemmacrophagepost-transcriptionalRNA

Identifiers

PMID40592687
PMCPMC12377350

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.