ArticleRenal failure2025
Causal relationship and shared genetic pathways between diabetic kidney disease and cognitive impairment: a Mendelian randomization study.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundDiabetic kidney disease (DKD) may increase cognitive impairment (CI) risk, but causal evidence remains limited. We aimed to investigate this causality and elucidate underlying genetic mechanisms.
methodsBidirectional two-sample Mendelian randomization (MR) was performed using summary statistics from four DKD genome-wide association studies (GWAS) and a large-scale cognitive function GWAS. Sensitivity analyses (heterogeneity, pleiotropy, leave-one-out, and Steiger directionality tests) confirmed the robustness of the results. Multivariable MR was used to adjust for potential confounders. Genetic correlation was assessed via linkage disequilibrium score regression (LDSC). Shared loci and pathways were identified through colocalization and functional enrichment analyses.
resultsDKD significantly increased cognitive decline risk (inverse-variance weighted (IVW) OR range: 0.55-0.88; all
conclusionsThis study provides evidence supporting a causal relationship and genetic correlation between DKD and CI, while also identifying shared genetic features and biological pathways that may contribute to their association.
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