Evidence map›Paper›PMID 40592863›Full record

ArticleNature communications2025

Colistin enhances caspofungin antifungal efficacy against Aspergillus fumigatus by modulating calcium homeostasis and stress responses.

Laura Cristina García Carnero, Xingyue Li, Patrícia Alves de Castro, Camila Figueiredo Pinzan, Jonatas Erick Maimoni Campanella, Iran Malavazi, Mami Yoshimura, Luis Alberto Vega Isuhuaylas, Yoko Yashiroda, Charles Boone and 8 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Recent innovations and challenges in the treatment of fungal infections.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Laura Cristina García Carnero *Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Xingyue Li *Department of Clinical Laboratory, Nanjing Drum Tower Hospital, College of Life Science, Nanjing Normal University, Nanjing, Jiangsu, China.
Patrícia Alves de CastroFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Camila Figueiredo PinzanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Jonatas Erick Maimoni CampanellaDepartamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, São Paulo, Brazil.
Iran MalavaziDepartamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-4526-4961
Mami YoshimuraRIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Luis Alberto Vega IsuhuaylasDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Yoko YashirodaRIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Charles BooneRIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0002-3542-6760
Nir OsherovDepartment of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.ORCID http://orcid.org/0000-0002-0433-0096
Sara FallahDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0009-0002-1755-2656
Taylor DavieDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-2821-9269
Leah CowenDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-5797-0110
Ling LuDepartment of Clinical Laboratory, Nanjing Drum Tower Hospital, College of Life Science, Nanjing Normal University, Nanjing, Jiangsu, China. linglu@njnu.edu.cn.ORCID http://orcid.org/0000-0002-2891-7326
Thaila Fernanda Dos ReisFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil. thailaf@hotmail.com.ORCID http://orcid.org/0000-0002-7776-977X
Gustavo H GoldmanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil. ggoldman@usp.br.ORCID http://orcid.org/0000-0002-2986-350X

Funding

Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5M
Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2021/04977-5NIAID NIH HHS R01 AI153356
6 · The paper itself

Abstract

Fungal infections cause more than 2.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, by screening a collection of 5297 compounds derived from three chemical libraries, we demonstrate that the antibacterial agent colistin (COL) can potentiate the fungistatic echinocandins caspofungin (CAS) and anidulafungin, as well as the structurally distinct cell wall targeting antifungal ibrexafungerp against Aspergillus fumigatus. Chemical and genetic screenings revealed that protein kinase C and the transcription factor SltA are involved in the mechanism of action of COL. SltA is essential for coping with calcium-limiting conditions, and the addition of calcium rescues COL-susceptibility. COL + CAS decreases A. fumigatus infection in human pulmonary cells, Galleria mellonella, and Caenorhabditis elegans. In summary, we demonstrate that the mechanism of COL as a synergizer of CAS against A. fumigatus is the disruption of the cell membrane permeability and calcium homeostasis.

Indexed as

Antifungal AgentsAspergillus fumigatusCalciumCaspofunginColistinAnimalsAspergillosisCaenorhabditis elegansCell Membrane PermeabilityCell WallDrug SynergismEchinocandinsHomeostasisHumansMicrobial Sensitivity TestsMothsAntifungal AgentsCalciumCaspofunginColistinEchinocandinsProtein Kinase CTranscription Factors

Identifiers

PMID40592863
PMCPMC12214536

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.